MR-IMAGING AND SPECTROSCOPY FOR PROGNOSTIC EVALUATION IN SOFT-TISSUE SARCOMAS
MR-IMAGING AND SPECTROSCOPY FOR PROGNOSTIC EVALUATION IN SOFT-TISSUE SARCOMAS
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DOI：
10.1148/radiology.190.1.8259418
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发表时间：
1994-01-01
期刊：
影响因子：
19.7
通讯作者：
CHARLES, HC
中科院分区：
文献类型：
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作者：
SOSTMAN, HD;PRESCOTT, DM;CHARLES, HC
目得：为了能够预测肿瘤对特定treatment.MATERIALS和METHODS的反应：作者研究了氢-1 T2和磷-31磁共振（MR）光谱代谢测定作为20个人和10只狗软组织肉瘤预后指标的价值。所有患者均接受联合分割放射治疗和热疗。手术切除整个肿瘤在人类允许治疗前的T2和MR光谱参数与随后的组织学结果进行比较。对犬进行了长期临床随访（无手术干预），并将治疗前pH值与局部无复发生存期进行了比较。研究结果：治疗前的pH值和T2和最终的肿瘤坏死之间存在的关系，在人类和治疗前的pH值和时间流逝，直到局部failure in dogs.CONCLUSION：磁共振成像和光谱可能是有用的软组织肉瘤患者的预后治疗开始前。
PURPOSE: To enable prediction of tumor response to a particular treatment.MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in 20 humans and 10 dogs with soft-tissue sarcomas. All patients underwent combined fractionated radiation therapy and hyperthermia. Surgical resection of the entire tumor in humans allowed comparison of pretherapy T2 and MR spectroscopic parameters with subsequent histologic findings. Long-term clinical follow-up (no surgical intervention) was available with the dogs and allowed comparison of pretherapy pH with the duration of local relapse-free survival. RESULTS: A relationship exists between pretherapy pH and T2 and ultimate tumor necrosis in humans and pretherapy pH and time elapsed until local failure in dogs.CONCLUSION: MR imaging and spectroscopy could be useful in the prognosis of patients with soft-tissue sarcomas before therapy is initiated.