Oxygen-derived species: their relation to human disease and environmental stress.
Oxygen-derived species: their relation to human disease and environmental stress.
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DOI：
10.1289/ehp.94102s105
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发表时间：
1994-12
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
--
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自由基和其他活性氧 (ROS) 在人体内不断形成，通常用于有用的代谢目的。抗氧化防御可以抵御它们，但这些防御并不完全足够，修复活性氧损伤的系统也是必要的。轻度氧化应激通常会诱发抗氧化防御酶，但严重应激会对细胞内的脂质、蛋白质和 DNA 造成氧化损伤，导致 DNA 链断裂和钙离子代谢破坏等事件。氧化应激可能是由于接触有毒物质以及组织损伤本身引起的。臭氧、氮氧化物和香烟烟雾会造成氧化损伤；但它们破坏的分子靶点可能不一样。
Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes. Antioxidant defenses protect against them, but these defenses are not completely adequate, and systems that repair damage by ROS are also necessary. Mild oxidative stress often induces antioxidant defense enzymes, but severe stress can cause oxidative damage to lipids, proteins, and DNA within cells, leading to such events as DNA strand breakage and disruption of calcium ion metabolism. Oxidative stress can result from exposure to toxic agents, and by the process of tissue injury itself. Ozone, oxides of nitrogen, and cigarette smoke can cause oxidative damage; but the molecular targets that they damage may not be the same.