Expression of a mucociliary-specific epitope in human olfactory epithelium.
Expression of a mucociliary-specific epitope in human olfactory epithelium.
复制标题
人嗅觉上皮中粘液纤毛特异性表位的表达。
DOI：
10.1097/00001756-199306000-00005
复制
发表时间：
1993
期刊：
影响因子：
1.7
通讯作者：
Getchell,ML
中科院分区：
文献类型：
--
作者：
Getchell,TV;Chen,Y;Strotmann,J;Breer,H;Getchell,ML
一个嗅纤毛特异性表位定位在12名受试者的年龄范围从16周的妊娠到85岁，包括3与阿尔茨海默氏病的人嗅上皮的粘膜纤毛复合物的化学。嗅觉标记蛋白（OMP）的免疫反应性被用来识别嗅上皮;在16周龄胎儿的嗅觉受体神经元中的OMP免疫反应性是在人类妊娠中检测到OMP表达的最早时间点。结果表明，与气味转导相关的纤毛分子的表达和嗅觉受体神经元的功能成熟之间存在密切的耦合。
An olfactory ciliary-specific epitope was localized immunohistochemically in the mucociliary complex of human olfactory epithelium of 12 subjects ranging in age from 16 weeks of gestation to 85 years, including 3 with Alzheimer's disease. Immunoreactivity for olfactory marker protein (OMP) was used to identify olfactory epithelium; OMP immunoreactivity in olfactory receptor neurons in a 16-week old fetus is the earliest time point at which OMP expression has been detected in human gestation. The results suggest a close coupling between the expression of ciliary molecules associated with odorant transduction and the functional maturation of olfactory receptor neurons.