EFFECTS OF MAGNESIUM IONS ON CALCIUM AND PHOSPHORUS METABOLISM
EFFECTS OF MAGNESIUM IONS ON CALCIUM AND PHOSPHORUS METABOLISM
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DOI：
10.1152/ajplegacy.1968.214.2.348
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发表时间：
1968-01-01
影响因子：
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通讯作者：
CLARK, I
中科院分区：
文献类型：
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作者：
CLARK, I
研究了补充但无毒量的口服镁离子对成年雄性大鼠钙和磷代谢的影响。在动物习惯于其各自的饮食5天后，研究了12天的平衡期。如果饮食中含有足够量的钙，补充镁降低粪便钙（增加吸收）和增加尿钙的饮食水平的钙无关。补充镁的净效应是增加钙平衡。肠道钙吸收增加或高钙尿症的机制尚不清楚。补充镁对磷的吸收没有影响时，膳食磷是次优的，它增加了它时，膳食钙磷比低。镁对磷酸盐吸收的影响似乎是镁钙相互作用的结果。尿磷随镁摄入量的增加而降低。一般来说，镁增加磷平衡主要是由于肾脏保护P。
The effects of supplemental but nontoxic amounts of orally administered Mg ions on Ca and phosphate metabolism of adult male rats fed diets containing varied amounts of Ca and P were studied. A 12-day balance period was investigated after the animals were habituated to their respective diets for 5 days. If the diets contained adequate amounts of Ca, supplemental Mg decreased fecal Ca (increased absorption) and increased urinary Ca irrespective of the dietary level of Ca. The net effect of supplemental Mg was to increase Ca balance. The mechanism for the increased absorption of Ca from the intestinal tract or the hypercalciuria is not known. Supplemental Mg had no effect on P absorption when dietary P was suboptimal; it increased it when the dietary Ca-to-P ratio was low. The effects of Mg on phosphate absorption appear to be the result of a Mg-Ca interaction. Urinary P decreased with increasing Mg intake. In general, Mg increased P balance primarily as a result of renal conservation of P.