Women, loneliness, and incident coronary heart disease.
Women, loneliness, and incident coronary heart disease.
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DOI：
10.1097/psy.0b013e3181b40efc
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发表时间：
2009-10
影响因子：
3.3
通讯作者：
Kubzansky LD
中科院分区：
文献类型：
--
作者：
Thurston RC;Kubzansky LD
在对男性和女性的社区样本进行19年的随访期后，研究孤独与冠心病(CHD)发病风险之间的关系。孤独是人们感觉到的实际社会关系和理想社会关系之间的差异，它与几种不利的健康后果有关。然而，以前还没有研究在社区样本中对男性和女性进行前瞻性研究，以检验孤独和冠心病事件之间的关系。使用第一次全国健康和营养调查及其后续研究(n=3003)的数据来检验假设。由抑郁症流行病学研究中心的一个项目评估的孤独感和协变量来自基线访谈。冠心病事件来源于19年来的住院记录/死亡证明。使用COX比例风险模型对假设进行评估。在女性中，高度孤独感与发生冠心病的风险增加有关(高：危险比=1.76，95%可信区间=1.17？2.63；中等：危险比=0.98，95%可信区间=0.64？1.49；参考：低)，控制年龄、种族、教育、收入、婚姻状况、高血压、糖尿病、胆固醇、体力活动、吸烟、饮酒、收缩和舒张压以及体重指数。研究结果持续存在，此外还控制了抑郁症状。在男性中没有观察到明显的关联。在控制了多个混杂因素后，孤独感与冠心病发病风险的增加具有前瞻性的相关性。女性中的孤独感可能值得临床关注，不仅因为它对生活质量的影响，而且还因为它对心血管健康的潜在影响。
To examine associations between loneliness and risk of incident coronary heart disease (CHD) over a 19-year follow-up period in a community sample of men and women. Loneliness, the perceived discrepancy between actual and desired social relationships, has been linked to several adverse health outcomes. However, no previous research has prospectively examined the association between loneliness and incident CHD in a community sample of men and women. Hypotheses were examined using data from the First National Health and Nutrition Survey and its follow-up studies (n = 3003). Loneliness, assessed by one item from the Center for Epidemiologic Studies of Depression scale, and covariates were derived from baseline interviews. Incident CHD was derived from hospital records/death certificates over 19 years of follow-up. Hypotheses were evaluated, using Cox proportional hazards models. Among women, high loneliness was associated with increased risk of incident CHD (high: hazard ratio = 1.76, 95% Confidence Interval = 1.17â2.63; medium: hazard ratio = 0.98, 95% Confidence Interval = 0.64â1.49; reference: low), controlling for age, race, education, income, marital status, hypertension, diabetes, cholesterol, physical activity, smoking, alcohol use, systolic and diastolic blood pressures, and body mass index. Findings persisted additionally controlling for depressive symptoms. No significant associations were observed among men. Loneliness was prospectively associated with increased risk of incident CHD, controlling for multiple confounding factors. Loneliness among women may merit clinical attention, not only due to its impact on quality of life but also its potential implications for cardiovascular health.