CD10+fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma
CD10+fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma
复制标题
DOI：
10.1111/j.1365-2559.2009.03398.x
复制
发表时间：
2009-10-01
期刊：
影响因子：
6.4
通讯作者：
Tsuneyoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Nishihara, Yunosuke;Aishima, Shinichi;Tsuneyoshi, Masazumi
目的：为探讨胆管癌（CC）中肿瘤相关成纤维细胞CD 10表达的意义，采用免疫组化方法检测了167例肝内、肝外CC和29例胆管发育不良患者的成纤维细胞CD 10表达，并与临床病理参数进行比较。CD 10在周围型肝内癌、肝门型肝内癌和肝外型肝内癌中的表达率分别为5.7%（4/70）、29.2%（14/48）和57.1%（28/49）。在胆管发育不良中，肝门部4.3%（1/23）和肝外胆管20%（3/15）的成纤维细胞表达CD 10。CD 10的表达与CC的解剖位置密切相关，在肝门部胆管周围浸润型和低分化型CC中，CD 10的表达率分别为P < 0.0001和P = 0.0151。CD 10在CC中的表达高于肝门胆管发育不良（P = 0.0365）和肝外胆管发育不良（P = 0.0262）。CD 10表达不是CC的预后指标。结论：我们认为，CD 10+成纤维细胞更多地参与了肝门和肝外CC的进展比周围肝内CC。
Aims: To identify the role of CD10 expression of tumour-associated fibroblastic cells in the progression of cholangiocarcinoma (CC).Methods and results: The CD10 expression of fibroblastic cells was investigated immunohistochemically in 167 cases of intrahepatic and extrahepatic CC and 29 cases of biliary dysplasia, comparing the clinicopathological parameters. CD10 expression of fibroblastic cells was observed in 5.7% (4/70) of peripheral intrahepatic CC, 29.2% (14/48) of hilar intrahepatic CC, and 57.1% (28/49) of extrahepatic CC. As for biliary dysplasia, CD10 expression of fibroblastic cells was observed in 4.3% (1/23) in the hepatic hilum and 20% (3/15) in the extrahepatic bile duct. CD10 expression had a strong relationship with the anatomical location of CC, and was more frequently detected in the periductal infiltrating type of hilar intrahepatic CC (P < 0.0001) and in less differentiated cases in extrahepatic CC (P = 0.0151). CD10 expression was observed more frequently in CC than in biliary dysplasia of hepatic hilum (P = 0.0365) and extrahepatic bile duct (P = 0.0262). CD10 expression was not a prognostic indicator in CC.Conclusions: We suggest that CD10+ fibroblasts are more involved in the progression of hilar and extrahepatic CC than of peripheral intrahepatic CC.