Isolation and characterization of the Notch ligand Delta4
Isolation and characterization of the Notch ligand Delta4
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DOI：
10.1006/excr.2000.5034
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发表时间：
2000-11-01
影响因子：
3.7
通讯作者：
McCarthy, S
中科院分区：
文献类型：
--
作者：
Rao, PK;Dorsch, M;McCarthy, S
Noch信号在多种发育过程中起着关键作用。在脊椎动物中，多个Notch受体和多个配体的存在突显了这一过程的复杂性，每个受体和配体都显示出不同的表达谱。此外，配体还可以细分为两个家族，锯齿/锯齿家族和Delta家族。在这里，我们提出了一种新的Notch配体，Delta4的分离。表达分析表明，小鼠Delta4在胚胎发育期间的眼睛和肺以及成年鼠的心、肺、肝和肾中都有高表达。在功能上，Delta4与Jagged1没有区别，因为它通过Notch1和DNA结合蛋白CSL抑制肌肉生成和刺激转录。(C)2000年学术出版社。
Notch signaling plays a critical role in a variety of developmental programs. In vertebrates, the complexity of the process is underscored by the existence of multiple Notch receptors and multiple ligands, each of which displays a distinct expression profile. Furthermore, the ligands can be subdivided into two families, the Serrate/Jagged family and the Delta family. Here we present the isolation of a novel Notch ligand, Delta4. Expression analyses indicate that mouse Delta4 is highly expressed in the eye and lung during embryogenesis and in the heart, lung, liver, and kidney of the adult. Functionally, Delta4 is indistinguishable from Jagged1 in its abilities to inhibit myogenesis and to stimulate transcription through Notch1 and the DNA binding protein CSL. (C) 2000 Academic Press.