PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA‐containing natural products in actinomycetes
PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA‐containing natural products in actinomycetes
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DOI：
10.1111/jam.12217
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发表时间：
2013-07
影响因子：
4
通讯作者：
H. Wang;Y.-Y. Chen-Y.;L. Ge;T. Fang;J. Meng;Z. Liu;Xinlei Fang;S. Ni;C. Lin;Y-Y Wu-Y
中科院分区：
文献类型：
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作者：
H. Wang;Y.-Y. Chen-Y.;L. Ge;T. Fang;J. Meng;Z. Liu;Xinlei Fang;S. Ni;C. Lin;Y-Y Wu-Y
安莎霉素是一类大环内酰胺类抗生素，由I型聚酮合酶（PKS）以3-氨基-5-羟基苯甲酸（AHBA）为起始单元合成。该家族的大多数成员具有很强的抗微生物、抗真菌、抗癌和/或抗病毒活性。我们的目标是从放线菌中发现新的安莎霉素和/或其他含有AHBA的天然产物。
Ansamycins are a family of macrolactams that are synthesized by type I polyketide synthase (PKS) using 3‐amino‐5‐hydroxybenzoic acid (AHBA) as the starter unit. Most members of the family have strong antimicrobial, antifungal, anticancer and/or antiviral activities. We aimed to discover new ansamycins and/or other AHBA‐containing natural products from actinobacteria.