The status of spectral EEG abnormality as a diagnostic test for schizophrenia
The status of spectral EEG abnormality as a diagnostic test for schizophrenia
复制标题
DOI：
10.1016/j.schres.2007.11.020
复制
发表时间：
2008-02-01
影响因子：
4.5
通讯作者：
Iacono, William
中科院分区：
文献类型：
--
作者：
Boutros, Nash N.;Arfken, Cynthia;Iacono, William
目标：进行了文献综述，以确定是否EEG频谱异常是一致的，足以保证额外的努力，对他们发展成为一个临床诊断测试schizophrenia.Methods：五十三篇论文符合纳入审查标准，15个被列入一个荟萃分析的EEG偏差的显着程度相比，健康对照。研究进行了分类的基础上的4步方法的基础上的指导方针，用于评估的临床实用性的诊断test.Results：我们的审查和荟萃分析显示，大多数的异常复制在预期的方向与最一致的结果有关的增加优势缓慢的节奏在精神分裂症患者。这种效应在未用药患者中保持一致。只有少数研究提供了关于在区分经常出现在与精神分裂症相同的鉴别诊断列表上的精神疾病时发现的灵敏度和特异性的数据（第3步研究）。未发现使用标准化评估标准的多中心研究（第4步研究）。结论：需要额外的第3步和第4步研究来得出关于EEG频谱异常作为精神分裂症诊断测试的有用性的结论（C）2007 Elsevier B.V.保留所有权利。
Objective: A literature review was conducted to ascertain whether or not EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia.Methods: Fifty three papers met criteria for inclusion into the review and 15 were included in a meta-analysis of the degree of significance of EEG deviations as compared to healthy controls. Studies were classified based on a 4-step approach based on guidelines for evaluating the clinical usefulness of a diagnostic test.Results: Our review and meta-analysis revealed that most of the abnormalities are replicated in the expected directions with the most consistent results related to the increased preponderance of slow rhythms in schizophrenia patients. This effect remained consistent in un-medicated patients. Only a small number of studies provided data on the sensitivity and specificity of the findings in differentiating among the psychiatric disorders that frequently appear on the same differential diagnostic list as schizophrenia (Step 3 studies). No multicenter studies using standardized assessment criteria were found (Step 4 studies).Conclusions: Additional Step 3 and Step 4 studies are needed to draw conclusions on the usefulness of EEG spectral abnormalities as a diagnostic test for schizophrenia (C) 2007 Elsevier B.V. All rights reserved.