Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis.
Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis.
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DOI：
10.1513/pats.200808-088rm
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发表时间：
2009-05-01
期刊：
影响因子：
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通讯作者：
Kern, Robert C
中科院分区：
文献类型：
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作者：
Schleimer, Robert P;Kato, Atsushi;Kern, Robert C
本综述的目的是讨论最近的研究结果的上气道和鼻窦的慢性鼻窦炎（CRS）的人在文献的背景下。CRS是影响近3000万美国人的慢性炎性病症，并且通常对抗生素和糖皮质激素的治疗具有抗性（Meltzer EO和同事，J Allergy Clin Immunol 2004;114：155-212）。我们已经形成了一个由耳鼻喉科医生，过敏症专家和基础科学家组成的合作，以解决这种疾病中发生的潜在免疫和炎症过程，并可能对此负责。我们工作的主要重点是关注鼻窦和上呼吸道上皮细胞作为免疫和炎症反应的介质和调节剂的作用。我们不打算在此提供该领域文献的全面综述，但我们将尝试将我们的工作置于他人发现的背景下（Kato A和Schleimer RP，Curr Opin Immunol 2007;19：711-720; Schleimer RP和同事，J Allergy Clin Immunol 2007;120：1279-1284）。特别是，我们讨论的证据表明，上皮细胞的反应改变CRS，包括相关的树突状细胞，T细胞，B细胞，和屏障功能的调节。
The purpose of this review is to discuss recent findings made during studies of the upper airways and sinuses of people with chronic rhinosinusitis (CRS) in the context of the literature. CRS is a chronic inflammatory disorder affecting nearly 30 million Americans and is generally resistant to therapy with antibiotics and glucocorticoids (Meltzer EO and coworkers, J Allergy Clin Immunol 2004;114:155-212). We have formed a collaboration that consists of otolaryngologists, allergists, and basic scientists to address the underlying immunologic and inflammatory processes that are occurring in, and possibly responsible for, this disease. The main emphasis of our work has been to focus on the roles that epithelium, in the sinuses and upper airways, plays as both a mediator and regulator of immune and inflammatory responses. It is not our intention here to provide a comprehensive review of the literature in this area, but we will try to put our work in the context of the findings of others (Kato A and Schleimer RP, Curr Opin Immunol 2007;19:711-720; Schleimer RP and coworkers, J Allergy Clin Immunol 2007;120:1279-1284). In particular, we discuss the evidence that epithelial cell responses are altered in CRS, including those relevant to regulation of dendritic cells, T cells, B cells, and barrier function.