Neural ensembles in navigation: From single cells to population codes
Neural ensembles in navigation: From single cells to population codes
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DOI：
10.1016/j.conb.2022.102665
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发表时间：
2022-12-19
影响因子：
5.7
通讯作者：
Giocomo, Lisa M.
中科院分区：
文献类型：
--
作者：
Jones, Emily A. Aery;Giocomo, Lisa M.
大脑可以通过单个神经元的放电以及神经元群的协调放电来表示行为相关信息。海马体和相关皮质区域的神经元参与各种类型的神经元群来支持导航。这些集合类型包括单细胞代码、群体代码、时间压缩序列、行为序列和印迹。我们提出了集体射击的生理基础和行为相关性。我们讨论这些传统的集成定义如何由于所做出的基本假设和抽象而限制或扩展潜在的分析。我们强调编码如何在整体水平上发生变化，同时底层单细胞代码保持不变。最后，我们介绍了如何扩大集合定义以更好地理解大脑的全部复杂性。
The brain can represent behaviorally relevant information through the firing of individual neurons as well as the coordinated firing of ensembles of neurons. Neurons in the hippocampus and associated cortical regions participate in a variety of types of ensembles to support navigation. These ensemble types include single cell codes, population codes, timecompressed sequences, behavioral sequences, and engrams. We present the physiological basis and behavioral relevance of ensemble firing. We discuss how these traditional definitions of ensembles can constrain or expand potential analyses due to the underlying assumptions and abstractions made. We highlight how coding can change at the ensemble level while underlying single cell codes remain intact. Finally, we present how ensemble definitions could be broadened to better understand the full complexity of the brain.