Melanoma Risk in Relation to Use of Sunscreen or Other Sun Protection Methods
Melanoma Risk in Relation to Use of Sunscreen or Other Sun Protection Methods
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DOI：
10.1158/1055-9965.epi-11-0705
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发表时间：
2011-12-01
影响因子：
3.8
通讯作者：
Anderson, Kristin E.
中科院分区：
文献类型：
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作者：
Lazovich, DeAnn;Vogel, Rachel Isaksson;Anderson, Kristin E.
背景：支持防晒霜预防黑色素瘤的流行病学证据仅限于一项小型试验；病例对照研究报告了相互矛盾的结果。很少研究与黑色素瘤相关的防晒霜使用模式或替代防晒方法。方法：在一项基于人群的病例对照研究中，参与者（1,167 例病例；1,101 名对照）报告了每 10 岁户外活动相关防晒霜的使用情况、防晒霜模式（SPF15+、用量、皮肤覆盖、重新涂抹、常规使用）以及其他防晒方法的使用（如帽子、长袖衬衫、呆在阴凉处）。分数是各个活动和/或几十年的平均分；最近二十年的得分被用来将个人分类为非用户、不一致用户或最佳用户。计算了病例和对照之间的调整后平均得分差异，以及最佳使用者、不一致者与非使用者之间黑色素瘤的 OR 和 95% CI。 结果：防晒霜、防晒霜图案或其他防晒方法的平均得分较低，但对照组的平均得分高于 SPF15+ 防晒霜 (P = 0.03) 和其他防晒方法 (P = 0.006) 的病例。除常规防晒霜外，防晒霜最佳使用和大多数防晒霜模式的调整后 OR 为零或相对较弱（调整后 OR = 0.44，95% CI：0.23-0.86）。最佳使用其他防晒方法与黑色素瘤呈负相关（调整后 OR = 0.59，95% CI：0.44-0.78）。结论：最佳使用常规防晒霜或其他防晒方法与黑色素瘤风险降低密切相关；结果受到常规使用防晒霜的受试者数量较少以及其他防晒方法缺乏特异性的限制。影响：改善防晒霜实践和鼓励避免阳光照射的策略可能对预防黑色素瘤很重要。癌症流行病学生物标志物20（12）； 2583-93。 (C) 2011 年 AACR。
Background: Epidemiologic evidence supporting sunscreen for melanoma prevention is limited to one small trial; case-control studies report conflicting results. Sunscreen usage patterns or alternative sun protection methods have rarely been studied in relation to melanoma.Methods: In a population-based case-control study, participants (1,167 cases; 1,101 controls) reported for each decade year of age outdoor activity-related sunscreen use, sunscreen patterns (SPF15+, amount, skin coverage, reapplication, routine use), and use of other sun protection methods (like hats, long-sleeved shirts, staying in the shade). Scores were averaged across activities and/or decades; scores in the most recent two decades were used to classify individuals as non-, inconsistent-or optimal users. Adjusted mean score differences between cases and controls, and ORs and 95% CIs for melanoma among optimal-, inconsistent-versus nonusers were calculated.Results: Mean scores for sunscreen, sunscreen patterns or other sun protection methods were low, but higher among controls than cases for SPF15+ sunscreen (P = 0.03) and other sun protection methods (P = 0.006). Adjusted ORs for optimal use of sunscreen and most sunscreen patterns were null or relatively weak, except for routine sunscreen (adjusted OR = 0.44, 95% CI: 0.23-0.86). Optimal use of other sun protection methods was inversely associated with melanoma (adjusted OR = 0.59, 95% CI: 0.44-0.78).Conclusions: Optimal use of routine sunscreen or other sun protection methods were most strongly associated with decreased melanoma risk; results are limited by the small number of subjects who used sunscreen routinely and lack of specificity regarding other sun protection methods.Impact: Both improving sunscreen practices and encouraging sun avoidance strategies may be important for melanoma prevention. Cancer Epidemiol Biomarkers Prev; 20(12); 2583-93. (C) 2011 AACR.