Regulatory 3' Untranslated Regions of Bacterial mRNAs.
Regulatory 3' Untranslated Regions of Bacterial mRNAs.
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DOI：
10.3389/fmicb.2017.01276
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发表时间：
2017
影响因子：
5.2
通讯作者：
Sun YC
中科院分区：
文献类型：
--
作者：
Ren GX;Guo XP;Sun YC
mRNA的非翻译区（UTR）包含与基因表达的转录后和翻译调控相关的重要特征。大多数关于细菌UTR的研究都集中在5′端区域，然而，3′端UTR最近作为一类新的转录后调控元件出现。发现3′ UTR调节其自身mRNA的衰变和翻译起始。此外，3′ UTR构成了丰富的小调控RNA库，调节靶基因的表达。在当前的综述中，我们描述了几个最近发现的细菌调控3′ UTR的例子，讨论了它们的作用模式，并说明了它们如何在各种环境中促进基因调控。
The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5′regions; however, 3′UTRs have recently emerged as a new class of post-transcriptional regulatory elements. 3′UTRs were found to regulate the decay and translation initiation in their own mRNAs. In addition, 3′UTRs constitute a rich reservoir of small regulatory RNAs, regulating target gene expression. In the current review, we describe several recently discovered examples of bacterial regulatory 3′UTRs, discuss their modes of action, and illustrate how they facilitate gene regulation in various environments.