Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
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DOI：
10.1002/cne.20652
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发表时间：
2005-09-05
影响因子：
2.5
通讯作者：
Shepherd, GM
中科院分区：
文献类型：
--
作者：
Xu, FQ;Schaefer, M;Shepherd, GM
一般认为，主要嗅觉系统处理常见气味，辅助嗅觉系统专门处理信息素。由于方法上的限制，这两个系统同时对相同刺激做出反应的潜力尚未得到充分探讨。在这里，我们研究这种现象，使用高分辨率功能磁共振成像（fMRI），同时揭示在主（MOB）和副嗅球（AOB）的气味和信息素的反应。常见的气味在MOB中引起强信号，在AOB中引起弱信号。已知的小鼠信息素2-庚酮在MOB和AOB中都引起强烈的信号。尿液气味，一个复杂的混合物的信息素和气味，引起显着的信号在有限的区域的MOB和大区域的AOB。功能磁共振成像结果表明，主要和辅助嗅觉系统可能会响应挥发性化合物，但具有不同的选择性，这表明更大的整合比传统上认为的两个嗅觉通路。
It is generally believed that the main olfactory system processes common odors and the accessory olfactory system is specifically for pheromones. The potential for these two systems to respond simultaneously to the same stimuli has not been fully explored due to methodological limitations. Here we examine this phenomenon using high-resolution functional magnetic resonance imaging (fMRI) to reveal simultaneously the responses in the main (MOB) and accessory olfactory bulbs (AOB) to odors and pheromones. Common odorants elicited strong signals in the MOB and weak signals in the AOB. 2-Heptanone, a known mouse pheromone, elicited strong signals in both the MOB and AOB. Urine odor, a complicated mixture of pheromones and odorants, elicited significant signals in limited regions of the MOB and large regions of the AOB. The fMRI results demonstrate that both the main and the accessory olfactory systems may respond to volatile compounds but with different selectivity, suggesting a greater integration of the two olfactory pathways than traditionally believed.