Shifts in myeloarchitecture characterise adolescent development of cortical gradients
Shifts in myeloarchitecture characterise adolescent development of cortical gradients
复制标题
DOI：
10.7554/elife.50482
复制
发表时间：
2019-11-14
期刊：
影响因子：
7.7
通讯作者：
Bullmore, Edward T.
中科院分区：
文献类型：
--
作者：
Paquola, Casey;Bethlehem, Richard Ai;Bullmore, Edward T.
我们研究了青少年和年轻人的加速纵向队列（n = 234，两个时间点），以研究骨髓结构的动态重构。使用磁化转移（MT）数据（髓磷脂敏感的磁共振成像对比）生成皮质内轮廓。深度特定皮质内轮廓的混合效应模型证明了两个独立的过程：i）MT 总体增加，ii）与中深层信号增强相关的 MT 轮廓平坦化，特别是在异模态和单模态关联皮质中。这种发展独立于形态变化。发现中深层增强的 MT 与少突胶质细胞的基因表达标记在空间上特异性共定位。区域间协方差分析表明，这些皮质内的变化导致高阶系统与低阶系统的逐渐分化。皮质内骨髓结构发育的深度依赖性轨迹有助于人类新皮质结构层次的成熟，为青少年发育提供了一个模型，连接了大脑组织的微观结构和宏观尺度。
We studied an accelerated longitudinal cohort of adolescents and young adults (n = 234, two time points) to investigate dynamic reconfigurations in myeloarchitecture. Intracortical profiles were generated using magnetization transfer (MT) data, a myelin-sensitive magnetic resonance imaging contrast. Mixed-effect models of depth specific intracortical profiles demonstrated two separate processes i) overall increases in MT, and ii) flattening of the MT profile related to enhanced signal in mid-to-deeper layers, especially in heteromodal and unimodal association cortices. This development was independent of morphological changes. Enhanced MT in mid-to-deeper layers was found to spatially co-localise specifically with gene expression markers of oligodendrocytes. Interregional covariance analysis revealed that these intracortical changes contributed to a gradual differentiation of higher-order from lower-order systems. Depth-dependent trajectories of intracortical myeloarchitectural development contribute to the maturation of structural hierarchies in the human neocortex, providing a model for adolescent development that bridges microstructural and macroscopic scales of brain organisation.