Increased HLA‐DR+ T‐lymphocyte population in peripheral blood of alopecia areata
Increased HLA‐DR+ T‐lymphocyte population in peripheral blood of alopecia areata
复制标题
斑秃外周血中 HLA-DR+ T 淋巴细胞数量增加
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
H. Ogawa
中科院分区：
文献类型：
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作者：
R. Imai;J. Miura;K. Takamori;H. Ogawa
采用双直接免疫荧光法检测斑秃患者外周血中活化T细胞亚群[人类白细胞抗原-DR+-Leu4+细胞、白细胞介素2受体阳性(IL-2R+)-Leu4+细胞]。58例再障患者分为3种类型：非活动性单个斑秃(1型)、活动性多发性斑秃(MAA)皮损、活动性全秃发(AT)(2型)和慢性全面性脱发(AU)(3型)。与正常对照组相比，2型和3型再障患者的HLADR+Leu4+细胞百分率较高，而1型再障患者未检测到。提示活动期MAA、AT和慢性AU患者外周血中T细胞被激活。
The populations of activated T‐cell subsets [HLA‐DR+ ‐Leu 4+ cells, interleukin 2 receptor positive (IL‐2R +)‐Leu 4+ cells] in the peripheral blood of patients with alopecia areata (AA) were investigated using double direct immunofluorescence staining. Fifty‐eight patients with AA were classified into one of three types: those with inactive single AA (type 1) lesions, active multiple alopecia areata (MAA) lesions and active alopecia totalis (AT) (type 2) and chronic alopecia universalis (AU) (type 3). Compared to normal controls, high percentages of HLA‐DR+‐Leu 4+ cells were detected in types 2 and 3 AA patients, but not in type 1 AA patients. These findings suggest that T cells are activated in the peripheral blood of active MAA, AT and chronic AU.