Serum levels of IgA1 and IgA2 in children and in patients with IgA deficiency.
Serum levels of IgA1 and IgA2 in children and in patients with IgA deficiency.
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儿童和 IgA 缺乏症患者的 IgA1 和 IgA2 血清水平。
DOI：
10.1016/0161-5890(83)90038-x
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发表时间：
1983
影响因子：
3.6
通讯作者：
Douglas,SD
中科院分区：
文献类型：
--
作者：
Conley,ME;Arbeter,A;Douglas,SD
用固相放射免疫法测定了110例3个月~10岁儿童血清中的IgA1和IgA2水平。所有样本中均可检测到IgA1和IgA2，且均随年龄增长而增加。血清总IgA中以IgA2为主的比例不随年龄变化，儿童组(15.05±10.2%)与成人组(15.86±7.98%)相同。在兄弟姐妹中，血清IgA为IgA2的比例比在整个组内的变化要小得多(P<；0.005)。在16例Ig A缺乏症患者中，血清Ig A为Ig A1或Ig A2的比例差异很大。5例患者的IgA2占IgA的50%以上，另有5例患者的IgA低于7%。这些发现表明，血清IgA1和IgA2浓度的调节是复杂的，并受到遗传因素和可能其他未知因素的影响。
Serum levels of IgA1and IgA2were measured by solid phase radioimmunoassay in samples from 110 children between 3 months and 10 years of age. Both IgA1and IgA2were detectable in all samples, and both IgA1and IgA2increased with increasing age. The percent of total serum IgA that was IgA2did not change with age and was the same in samples from children (15.05 ± 10.2%) as in samples from adults (15.86 ± 7.98%). The proportion of serum IgA that was IgA2was much less variable within sibships than within the group at large (P< 0.005). In the 16 patients with IgA deficiency, the proportion of serum IgA that was IgA1or IgA2was highly variable. IgA2constituted more than 50% of the IgA in 5 patients and less than 7% of the IgA in an additional 5 patients. These findings suggest that regulation of serum concentrations of IgA1and IgA2is complex and influenced by genetic factors and probably other unidentified factors.