Aerobic exercise and HDL2-C:: A meta-analysis of randomized controlled trials
Aerobic exercise and HDL2-C:: A meta-analysis of randomized controlled trials
复制标题
DOI：
10.1016/j.atherosclerosis.2005.04.005
复制
发表时间：
2006-01-01
期刊：
影响因子：
5.3
通讯作者：
Kelley, KS
中科院分区：
文献类型：
--
作者：
Kelley, GA;Kelley, KS
目的：采用荟萃分析方法研究有氧运动对成年人高密度脂蛋白2-C的影响。研究来源：（1）计算机文献检索;（2）交叉引用，检索到的文章;（3）手工检索;（4）专家审查我们的参考文献列表。研究选择：（1）随机对照试验;（2）有氧运动≥ 8周;（3）有氧运动≥ 8周。（3）≥ 18岁的成年人;（4）以期刊、论文或硕士论文形式发表的研究;（5）1955年1月1日至2003年1月1日期间以英文发表的研究;（6）空腹状态下HDL 2-C的评估。结果：19项随机对照试验，代表20个HDL 2-C结果从984名男性和女性（516运动，468对照）进行了汇总分析。使用随机效应建模和bootstrap置信区间（BCI），观察到HDL 2-C统计学显著增加约11%（（x）超过条形图+/- S.E.M.，2.6+/- 0.9 mg/dl，95% BCI，1.0-4.4 mg/dl）。每个研究从模型中删除一次，结果仍然具有统计学意义。HDL 2-C的增加与体重、体重指数（kg/m2）和体脂百分比的降低无关。结论：有氧运动可增加成年人的HDL 2-C。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: Use the meta-analytic approach to examine the effects of aerobic exercise on high-density lipoprotein two cholesterol (HDL2-C) in adults.Study sources: (1) Computerized literature searches; (2) cross-referencing fro, retrieved articles; (3) hand-searching; ; and (4) expert review of our reference list.Study selection: (1) Randomized controlled trials; (2) aerobic exercise >= 8 weeks; (3) adults >= 18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January I 1955 and January 1, 2003; and (6) assessment of HDL2-C in the fasting state.Data abstraction: All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results: Nineteen randomized controlled trials representing 20 HDL2-C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL2-C ((x) over bar +/- S.E.M., 2.6 +/- 0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL2-C were independent of decreases in body weight, body mass index (kg/m(2)), and percent body fat.Conclusion: Aerobic exercise increases HDL2-C in adults. (c) 2005 Elsevier Ireland Ltd. All rights reserved.