Rational design of silicon structures for optically controlled multiscale biointerfaces
Rational design of silicon structures for optically controlled multiscale biointerfaces
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DOI：
10.1038/s41551-018-0230-1
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发表时间：
2018-07-01
影响因子：
28.1
通讯作者：
Tian, Bozhi
中科院分区：
文献类型：
--
作者：
Jiang, Yuanwen;Li, Xiaojian;Tian, Bozhi
硅基材料已广泛应用于生物领域。然而，由于对硅和生物材料之间界面上发生的复杂物理化学过程的基本了解有限，远程控制和无互连的硅配置很少被探索。在这里，我们描述了合理的设计原则，在生物学的指导下，建立基于硅的细胞内、细胞间和细胞外界面，其中硅和生物靶具有匹配的特性。我们专注于这些界面上的光诱导过程，并开发了一组矩阵来量化和区分大约30种不同硅材料在盐水中的电容、法拉第和热输出。我们发现，这些界面对于光控制的细胞内钙动力学、细胞骨架结构和运输、细胞兴奋性、脑片神经递质释放和体内脑活动的非遗传调控是有用的。
Silicon-based materials have been widely used in biological applications. However, remotely controlled and interconnect-free silicon configurations have been rarely explored, because of limited fundamental understanding of the complex physicochemical processes that occur at interfaces between silicon and biological materials. Here, we describe rational design principles, guided by biology, for establishing intracellular, intercellular and extracellular silicon-based interfaces, where the silicon and the biological targets have matched properties. We focused on light-induced processes at these interfaces, and developed a set of matrices to quantify and differentiate the capacitive, Faradaic and thermal outputs from about 30 different silicon materials in saline. We show that these interfaces are useful for the light-controlled non-genetic modulation of intracellular calcium dynamics, of cytoskeletal structures and transport, of cellular excitability, of neurotransmitter release from brain slices and of brain activity in vivo.