Biomass-derived carbon helices induced phase transition in poly(N-ispropylacrylamide): A sustainable tailoring of coil-globule transition in thermoresponsive polymer.
Biomass-derived carbon helices induced phase transition in poly(N-ispropylacrylamide): A sustainable tailoring of coil-globule transition in thermoresponsive polymer.
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DOI：
10.1016/j.colsurfb.2019.110637
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
R. Yadav;Kanakaraj Aruchamy;D. Mondal;P. Venkatesu
中科院分区：
文献类型：
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作者：
R. Yadav;Kanakaraj Aruchamy;D. Mondal;P. Venkatesu
功能碳螺旋（FCHs）含有多种氧化官能团，直接来源于木质纤维素生物质，被证明是一种潜在的生态友好型生物分子。目前还没有研究报道生物质衍生的平台分子对聚合物热响应行为的影响，而聚合物在这一广阔的研究领域已被证明是携带各种药物递送应用、凝胶和组织工程的潜在候选者。聚（n -异丙基丙烯酰胺）（PNIPAM）是一种热敏聚合物，已被发现是承载各种上述应用的主流工具。本研究报告了一种无害的草本植物——宫草parthenium hysterophorus对PNIPAM热响应行为的强大影响。利用荧光光谱技术研究了聚合物结构周围碳螺旋提供的微环境。所得结果与FCHs浓度较高时极性增加直接相关，并进一步证实了荧光强度的降低。此外，为了更好地了解PNIPAM与FCHs之间的相互作用，采用了傅里叶变换红外光谱（FTIR）。动态光散射（DLS）分析了PNIPAM的水动力直径（dH），发现FCHs浓度越高，PNIPAM的粒径越大。差示扫描量热法（DSC）进一步证实了PNIPAM在FCHs中的低临界溶液温度（LCST）从34.7 °C下降到29.0 °C。利用场发射扫描电子显微镜（FESEM）和透射电子显微镜（TEM）了解了生物质衍生碳螺旋存在下PNIPAM的形态变化。PNIPAM-生物量的显微照片代表了PNIPAM与FCHs相互作用时的扰动形态。在本研究中，碳螺旋上的高氧化官能团对PNIPAM的构象相行为有重要影响。卷须状功能碳螺旋（TLFCHs）是导致PNIPAM低临界溶解温度（LCST）降低的唯一原因。我们的综合研究表明，生物质衍生的碳螺旋显著降低了PNIPAM的LCST 5 °C。最终，聚合物达到致密的球状构象和完全聚集状态。
Functional carbon helices (FCHs) containing various oxygenated functionalities derived directly from lignocellulosic biomass is proved to be a potential eco friendly candidate for biomolecules. No study reports the effect of biomass derived platform molecules on the thermoresponsive behavior of polymers, which have been proved potential candidates in carrying various drug delivery applications, gels, and tissue engineering in this vast area of research. Poly(N-isopropylacrylamide) (PNIPAM) is a thermoresponsive polymer that has been found to be a prevailing tool in carrying various aforesaid applications. This study reports a powerful impact on the thermoresponsive behavior of PNIPAM by a non-hazardous alternative form of a herbecious plantParthenium hysterophorus. Fluorescence spectroscopy was deployed to study the microenvironment provided by carbon helices around the polymer structure. The results obtained are directly correlating with the increased polarity with higher concentration of FCHs and further confirmed a decrease in fluorescence intensity. Moreover, for better understanding of interactions between PNIPAM and FCHs, Fourier transform infrared spectroscopy (FTIR) was employed. The analysis of hydrodynamic diameter (dH) was carried out by dynamic light scattering (DLS) and the aggregate size of PNIPAM was found to increase in higher concentration of FCHs. A decrease from 34.7 °C to 29.0 °C in the lower critical solution temperature (LCST) of PNIPAM in FCHs was further confirmed by differential scanning calorimetry (DSC). Field emission scanning electron microscopy (FESEM) and Transmission electron microscopy (TEM) were also taken into account to understand the morphological changes of PNIPAM in presence of biomass derived carbon helices. The micrographs of PNIPAM-biomass are representing a perturbed morphology of PNIPAM during interaction with FCHs. In this study, high degree of oxygenated functionalities on the carbon helices has a meaningful impact on the conformational phase behavior of PNIPAM. The tendril like functional carbon helices (TLFCHs) are uniquely causing a decrease in the lower critical solution temperature (LCST) of PNIPAM. Our combined study indicates that biomass derived carbon helices significantly decrease the LCST of PNIPAM by 5 °C. Ultimately, the polymer achieves compact globule conformational and complete aggregated state.