The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.
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作者：
胃肠道的粘膜表面持续暴露于微生物和饮食来源的巨大抗原负荷，但仍保持体内平衡。模式识别分子（PRM）在维持上皮屏障的完整性和促进粘膜免疫系统的成熟中具有关键作用。共生细菌调节参与维持上皮完整性、炎症反应和产生抗微生物肽的广泛基因的表达。缺乏PRM的小鼠可以发展肠道炎症，这取决于微生物群，而在人类中，PRM多态性与炎症性肠病加重有关。天然免疫应答和上皮屏障功能由PRM诱导的信号传导在多个水平上调节，从粘膜细胞或隔室上受体的选择性表达到负调节因子的表达。在这里，我们描述了最近的进展，我们的理解先天信号通路，特别是Toll样受体和核苷酸结合域和富含亮氨酸的重复在粘膜表面的受体。
The mucosal surfaces of the gastrointestinal tract are continually exposed to an enormous antigenic load of microbial and dietary origin, yet homeostasis is maintained. Pattern recognition molecules (PRMs) have a key role in maintaining the integrity of the epithelial barrier and in promoting maturation of the mucosal immune system. Commensal bacteria modulate the expression of a broad range of genes involved in maintaining epithelial integrity, inflammatory responses, and production of antimicrobial peptides. Mice deficient in PRMs can develop intestinal inflammation, which is dependent on the microbiota, and in humans, PRM polymorphisms are associated with exacerbated inflammatory bowel disease. Innate immune responses and epithelial barrier function are regulated by PRM-induced signaling at multiple levels, from the selective expression of receptors on mucosal cells or compartments to the expression of negative regulators. Here, we describe recent advances in our understanding of innate signaling pathways, particularly by Toll-like receptors and nucleotide-binding domain and leucine-rich repeat containing receptors at mucosal surfaces.
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影响因子：
4.8
作者：
Cetin, S;Ford, HR;Hackam, DJ
通讯作者：
Hackam, DJ
DOI：
10.1073/pnas.0611496104
发表时间：
2007-05-08
影响因子：
11.1
作者：
Duncan, Joseph A.;Bergstralht, Daniel T.;Ting, Jenny Pan-Yun
通讯作者：
Ting, Jenny Pan-Yun
影响因子：
3.1
作者：
Cario, E;Podolsky, DK
通讯作者：
Podolsky, DK
影响因子：
30.5
作者：
Franchi, Luigi;Amer, Amal;Nunez, Gabriel
通讯作者：
Nunez, Gabriel
影响因子：
56.9
作者：
Duerr, Richard H.;Taylor, Kent D.;Cho, Judy H.
通讯作者：
Cho, Judy H.