The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events
The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events
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DOI：
10.3109/13685538.2010.502270
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
T. Maeda;J. Oyama;Y. Higuchi;M. Koyanagi;M. Sasaki;T. Arima;K. Mimori;N. Makino
中科院分区：
文献类型：
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作者：
T. Maeda;J. Oyama;Y. Higuchi;M. Koyanagi;M. Sasaki;T. Arima;K. Mimori;N. Makino
据报道，外周血白细胞端粒长度和亚端粒甲基化状态与多种病理生理状态有关。然而，代谢性疾病的端粒参数与临床实验室数据之间的相关性还不是很清楚。本研究探讨外周血白细胞端粒长度与端粒亚甲基化状态的相关性，并对无心脑血管事件临床病史且合并代谢紊乱的男性门诊患者的实验室资料进行评估，以寻找较好的反映生物衰老的临床实验室指标。收集26例无心脑血管事件史的日本男性糖尿病、高脂血症患者的实验室资料，用甲基化敏感和不敏感的同裂异构体，用Southern印迹法检测其外周血白细胞端粒参数。评估了实验室数据和端粒参数之间的任何相关性。患者的胆红素和肌酸磷酸激酶水平与端粒和亚端粒参数的增龄性变化呈显著负相关。血清胆红素和肌酸磷酸激酶水平降低与以代谢紊乱患者端粒磨损为代表的基因组老化有关。
The telomere length and subtelomeric methylated status of peripheral blood leukocytes has been reported to be correlated with many kinds of pathophysiological conditions. However, the correlation between the telomeric parameters and clinical laboratory data in metabolic disorders is not well known. This study investigated the correlation between the telomere length and subtelomeric methylated status in peripheral leukocytes and the laboratory data of male outpatients with combined metabolic disorders and no clinical history of cardiovascular or cerebrovascular event were assessed, to find good clinical laboratory markers reflecting the biological aging. The laboratory data were collected in 26 Japanese male outpatients with diabetes mellitus and hyperlipidemia, and no history of cardiovascular or cerebrovascular event, and the telomeric parameters in their peripheral leukocytes were determined by Southern blot with methylation-sensitive and insensitive isoschizomers. Any correlations between the laboratory data and the telomeric parameters were assessed. The patients showed a significant negative correlation among the bilirubin and creatine phosphokinase with the aging-associate change of the telomeric and subtelomeric parameters. Lowered serum bilirubin and creatinine phosphokinase level correlated to genomic aging represented by telomere attrition of patients with metabolic disorders.