Visceral adipose tissue and markers of the insulin resistance syndrome in obese black and white teenagers
Visceral adipose tissue and markers of the insulin resistance syndrome in obese black and white teenagers
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DOI：
10.1038/oby.2000.34
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发表时间：
2000-07-01
期刊：
影响因子：
--
通讯作者：
Le, NA
中科院分区：
文献类型：
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作者：
Owens, S;Gutin, B;Le, NA
目的：为了确定内脏和全身肥胖，心血管健康，和标记物的胰岛素抵抗综合征在肥胖的黑人和白色teenages.Research方法和程序之间的关系：横断面调查81肥胖13- 16岁的青少年。内脏脂肪组织用磁共振成像测量，体脂百分比用双能X线吸收法测量。心血管健康通过次极量活动平板试验进行评估。分析空腹血样的脂质/脂蛋白和胰岛素。使用自动袖带获得静息血压。结果：内脏脂肪组织与以下不良水平显著相关：甘油三酯（r = 0.27，p < 0.05），总胆固醇（r = 0.27，p < 0.05），高密度脂蛋白胆固醇总胆固醇/高密度脂蛋白胆固醇比值（r =-0.26，p < 0.05）（r = 0.42，p < 0.01）、低密度脂蛋白胆固醇（r = 0.27，p < 0.05）、载脂蛋白B（r = 0.38，p < 0.01）和收缩压（r = 0.30，p < 0.01）。多元回归分析显示，内脏脂肪组织比体脂百分比更能解释脂蛋白的变化（例如，总胆固醇/高密度脂蛋白胆固醇比值r（2）= 0.13，P < 0.01;收缩压r（2）= 0.07，P < 0.05）。种族是血脂最有力的人口统计学预测因素（黑人中甘油三酯水平较低，r（2）= 0.15;黑人中高密度脂蛋白胆固醇水平较高，r（2）= 0.10;黑人中总胆固醇/高密度脂蛋白胆固醇水平较低，r（2）= 0.06）。心血管健康没有保留作为一个显着的预测指标的insulin resistance syndrome.Discussion：内脏肥胖和标记物之间的有害关系，在成年人中看到的胰岛素抵抗综合征已经存在于这些肥胖的年轻人。
Objective: To determine the relationships between visceral and general adiposity, cardiovascular fitness, and markers of the insulin resistance syndrome in obese black and white teenagers.Research Methods and Procedures: Cross-sectional survey of 81 obese 13- to 16-year-old youths. Visceral adipose tissue was measured with magnetic resonance imaging, and percentage body fat was measured with dual-energy X-ray absorptiometry. Cardiovascular fitness was assessed with a submaximal treadmill test. Easting blood samples were analyzed for lipids/lipoproteins and insulin. Resting blood pressure was obtained using an automated cuff.Results: Visceral adipose tissue was significantly correlated with unfavorable levels of: triacylglycerol (r = 0.27, p < 0.05), total cholesterol (r = 0.27, p < 0.05), high-density lipoprotein cholesterol (r = -0.26, p < 0.05), the ratio of total cholesterol/high-density lipoprotein cholesterol (r 0.42, p < 0.01), low-density lipoprotein cholesterol (r = 0.27, p < 0.05), apolipoprotein B (r = 0.38, p < 0.01), and systolic blood pressure (r = 0.30, p < 0.01). Multiple regression analyses revealed that visceral adipose tissue was more powerful than percentage body fat for explaining variance in lipoproteins (e.g., for the ratio of total cholesterol/high-density lipoprotein cholesterol, r(2) = 0.13, p < 0.01, and for systolic blood pressure, r(2) = 0.07, p < 0.05). Ethnicity was the most powerful of the demographic predictors for blood lipids (r(2) = 0.15 for triacylglycerol with lower levels in blacks; r(2) = 0.10 for high-density lipoprotein cholesterol with higher levels in blacks; r(2) = 0.06 for the ratio of total cholesterol/high-density lipoprotein cholesterol with lower levels in blacks). Cardiovascular fitness was not retained as a significant predictor of markers of the insulin resistance syndrome.Discussion: Some of the deleterious relationships between visceral adiposity and markers for the insulin resistance syndrome seen in adults were already present in these obese young people.