Initial characterization of a benchtop microPET system based on LYSO crystal arrays and Hamamatsu H8500 PS-PMTs
Initial characterization of a benchtop microPET system based on LYSO crystal arrays and Hamamatsu H8500 PS-PMTs
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DOI：
10.1016/j.nima.2009.01.086
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发表时间：
2009-06
影响因子：
1.4
通讯作者：
H. Alva-Sánchez;A. Martínez-Dávalos;E. Moreno-Barbosa;B. Hernández-Reyes;T. Murrieta;C. Ruiz-Trejo;M. Brandan;M. Rodríguez-Villafuerte
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文献类型：
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作者：
H. Alva-Sánchez;A. Martínez-Dávalos;E. Moreno-Barbosa;B. Hernández-Reyes;T. Murrieta;C. Ruiz-Trejo;M. Brandan;M. Rodríguez-Villafuerte
墨西哥国立自治大学菲西卡研究所目前正在开发用于小动物研究的微型PET系统。该项目的主要目标是建立一个具有成本效益的台式系统，可用于研究目的。基本设计使用现成的组件，并正在使用核仪器模块和内部构建的读出电路进行组装。探测模块是基于像素化闪烁体LYSO晶体阵列耦合到滨松H8500位置敏感的光电倍增管与电阻链读出系统。脉冲数字化是用一个商业快速模拟到数字数据采集板。测量了光电倍增管的均匀性、串扰和孔径函数。这些模块能够识别峰谷比为4：1的单个晶体（400个晶体中）。测得22 Na单晶体谱的能量分辨率为7%~ 15%，系统的死时间为17 ~ 42μs，分辨时间为1.16±0.01ns，与源体积有关。系统的设计和表征包括探测器的蒙特卡罗模拟。
A microPET system for small animal studies is currently being developed at Instituto de Física, UNAM. The main goal of this project is to build a cost-effective benchtop system that could be suitable for research purposes. The basic design uses off-the-shelf components and is being assembled using nuclear instrumentation modules and in-house built readout circuits. The detection modules are based on pixelated scintillator LYSO crystal arrays coupled to Hamamatsu H8500 position-sensitive photomultiplier tubes with a resistive chain readout system. Pulse digitization is performed with a commercial fast analogue-to-digital data acquisition board. The uniformity, cross-talk and aperture function of the photomultipliers have been measured. The modules are able to identify individual crystals (out of 400) with a 4-to-1 peak-to-valley ratio. The measured energy resolution of22Na spectra in individual crystals ranges from 7% to 15%; the dead time of the system is between 17 and 42μs depending on the source volume, and the resolving time is 1.16±0.01ns. The design and characterization of the system includes Monte Carlo simulations of the detectors.