SBA-15-collagen hybrid material for drug delivery applications
SBA-15-collagen hybrid material for drug delivery applications
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DOI：
10.1016/j.jnoncrysol.2006.03.111
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发表时间：
2006-09-15
影响因子：
3.5
通讯作者：
Sousa, E. M. B.
中科院分区：
文献类型：
--
作者：
Fagundes, L. B.;Sousa, T. G. F.;Sousa, E. M. B.
介孔材料的发展为将生物制剂引入二氧化硅结构和控制基质的释放动力学提供了新的可能性，因为其良好的孔结构，实际上，在这些陶瓷中引入适当的有机化合物已经在药物释放控制方面表现出了良好的效果。在本论文中，两种类型的材料被用来评价药物释放：SBA-15和杂化SBA-15-胶原。以阿替洛尔为模型药物，对样品进行体外释放试验。不同材料的释放模式存在显著差异，中孔中胶原的存在对释放速率有影响。(C)2006爱思唯尔B.V.保留所有权利。
The development of mesoporous materials offers new possibilities for incorporating biological agents into silica structures and controlling the release kinetics from the matrix due to its well-arranged pore architecture, Indeed, the introduction of appropriate organic compounds into these ceramics has presented excellent results regarding drug release control. In this paper, two types of materials were used to evaluate drug delivery: SBA-15 and a hybrid SBA-15-collagen. The samples were charged with atenolol as a model drug and in vitro release assays were carried out. Significant differences were observed between the release patterns of the different materials, and the release rate was influenced by the presence of collagen in the mesopores. (c) 2006 Elsevier B.V. All rights reserved.