Evolving mechanistic insights into galectin functions.
Evolving mechanistic insights into galectin functions.
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DOI：
10.1007/978-1-4939-1396-1_1
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Stowell SR
中科院分区：
文献类型：
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作者：
Arthur CM;Baruffi MD;Cummings RD;Stowell SR
半乳糖凝集素是一个进化古老的聚糖结合蛋白 (GBP) 家族，存在于所有动物中。尽管它们在 30 多年前就被发现了，但关于它们的生物学功能的想法仍在不断发展。目前的证据表明，半乳糖凝集素是唯一已知的游离存在于细胞质和细胞外的 GBP，参与多种细胞内和细胞外途径，有助于稳态、细胞更新、细胞粘附和免疫。在这里，我们从历史的角度回顾了对半乳糖凝集素生物学的不断发展的见解，并探讨了有关半乳糖凝集素生物学作用的当前证据。
Galectins are an evolutionarily ancient family of glycan-binding proteins (GBPs) and are found in all animals. Although they were discovered over 30 years ago, ideas about their biological functions continue to evolve. Current evidence indicates that galectins, which are the only known GBPs that occur free in the cytoplasm and extracellularly, are involved in a variety of intracellular and extracellular pathways contributing to homeostasis, cellular turnover, cell adhesion, and immunity. Here we review evolving insights into galectin biology from a historical perspective and explore current evidence regarding biological roles of galectins.