Atomic-Resolution Imaging of Small Organic Molecules on Graphene
Atomic-Resolution Imaging of Small Organic Molecules on Graphene
复制标题
DOI：
10.1021/acs.nanolett.2c00213
复制
发表时间：
2022-05-11
期刊：
影响因子：
10.8
通讯作者：
Huang, Pinshane Y.
中科院分区：
文献类型：
--
作者：
Kharel, Priti;Janicek, Blanka E.;Huang, Pinshane Y.
在这里，我们展示了石墨烯上有机小分子中轻元素的原子分辨率扫描透射电子显微镜（STEM）成像。我们使用低剂量，室温，像差校正的STEM成像2D单层和双层分子晶体，然后使用先进的图像处理方法从类似于102- 104个单个分子创建高质量的复合图像。在金属化卟啉和酞菁衍生物中，这些图像包含高达1.3 A分辨率的元素敏感对比度？足以取代单个碳和氮原子。重要的是，我们的方法可以应用于低分子量（类似于0.6 kDa）和纳米晶体域仅包含几百个分子，使其成为可能tosstudy系统的大晶体不能很容易地生长。我们的方法是通过低背景的石墨烯衬底实现的，我们表明这将分子的临界剂量增加了2- 7倍。这些结果为低剂量、原子分辨电子显微镜成像解决有机小分子结构提供了一条新的途径
Here, we demonstrate atomic-resolution scanning transmission electronmicroscopy (STEM) imaging of light elements in small organic molecules on graphene.We use low-dose, room-temperature, aberration-corrected STEM to image 2Dmonolayer and bilayer molecular crystals, followed by advanced image processingmethods to create high-quality composite images from similar to 102-104individual molecules.In metalated porphyrin and phthalocyanine derivatives, these images contain anelementally sensitive contrast with up to 1.3 A resolution???sufficient to distinguishindividual carbon and nitrogen atoms. Importantly, our methods can be applied tomolecules with low masses (similar to 0.6 kDa) and nanocrystalline domains containing just a few hundred molecules, making it possible tostudy systems for which large crystals cannot easily be grown. Our approach is enabled by low-background graphene substrates,which we show increase the molecules'critical dose by 2-7x. These results indicate a new route for low-dose, atomic-resolutionelectron microscopy imaging to solve the structures of small organic molecules