Alterations of the TP53 gene in gastric and esophageal carcinogenesis.
Alterations of the TP53 gene in gastric and esophageal carcinogenesis.
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DOI：
10.1155/2012/891961
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发表时间：
2012
影响因子：
--
通讯作者：
Silva AE
中科院分区：
文献类型：
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作者：
Bellini MF;Cadamuro AC;Succi M;Proença MA;Silva AE
TP53基因是一种重要的肿瘤抑制基因，是一种高效的转录因子，在维持遗传稳定性方面具有基础性作用。食道癌和胃癌的发展是一个多步骤的过程，导致基因改变的不断积累，最终导致恶变。因此，本研究强调了TP53基因的主要遗传改变在食道癌和胃癌发生中的作用。在这些变化中，高频率的TP53突变、杂合性丢失(LOH)、P53蛋白的过度表达以及由此导致的P53功能丧失可能是食道癌和胃癌的早期事件，也是判断预后和治疗反应的重要生物标志物。此外，TP53基因的单核苷酸多态(SNPs)与多种癌症的发生和预后有关，主要是TP53密码子72多态，其作用已被广泛研究与食道癌和胃癌的易感性有关。
TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis. Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH), overexpression of the p53 protein, and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response. Furthermore, Single Nucleotide Polymorphisms (SNPs) of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development.