Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications
Novel Poly(3-hydroxyoctanoate)/Poly(3-hydroxybutyrate) blends for medical applications
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DOI：
10.1016/j.reactfunctpolym.2013.03.019
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发表时间：
2013-10-01
影响因子：
5.1
通讯作者：
Roy, I.
中科院分区：
文献类型：
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作者：
Basnett, P.;Ching, K. Y.;Roy, I.
新型聚（3-羟基丁酸酯）/聚（3-羟基辛酸酯）共混物中含有不同数量的聚（3-羟基辛酸酯）P（3HO）和聚（3-羟基丁酸酯）P(3HB)，用于各种医疗应用。与纯P（3HO）相比，共混膜具有更高的拉伸强度和杨氏模量。混合膜的总体蛋白质吸附量和细胞活力也明显高于纯P（3HO）膜。混合膜中的水解降解速度更快，降解速率可能被定制，以达到特定医疗应用所需的最佳速率。因此，这些新型共混物被发现具有高度的表面、机械和热性能的生物相容性，适用于一系列潜在的医疗应用，这是医疗材料领域的一大进步。(C) 2013 Elsevier Ltd.版权所有。
Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate) blends were developed with varying amounts of Poly(3-hydroxyoctanoate), P(3HO) and Poly(3-hydroxybutyrate), P(3HB) for their potential use in various medical applications. These blend films exhibited higher tensile strength and Young's modulus values compared to neat P(3HO). The overall protein adsorption and % cell viability was also found to be significantly higher in the blend films than the neat P(3HO) film. Hydrolytic degradation was faster in the blend films and the degradation rate could potentially be tailored to achieve the optimum rate required for a particular medical application. Hence, these novel blends were found to be highly biocompatible with surface, mechanical and thermal properties suitable for a range of potential medical applications, a great step forward in the area of medical materials. (C) 2013 Elsevier Ltd. All rights reserved.