Associations between exposure to perfluoroalkyl substances and birth outcomes: A meta-analysis.
Associations between exposure to perfluoroalkyl substances and birth outcomes: A meta-analysis.
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DOI：
10.1016/j.chemosphere.2021.132909
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发表时间：
2021-11
期刊：
影响因子：
8.8
通讯作者：
Zesen Yang;Huan Liu;Qiao-yun Yang;Xi Chen;Weiqin Li;Junhong Leng;N. Tang
中科院分区：
文献类型：
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作者：
Zesen Yang;Huan Liu;Qiao-yun Yang;Xi Chen;Weiqin Li;Junhong Leng;N. Tang
尽管先前的荟萃分析表明，产前PFASs暴露与出生体重下降有关，但产前PFASs暴露对出生结局的影响尚未得到充分探讨。我们对2021年3月21日之前从Embase，PubMed和Web of Science中检索的23项合格研究进行了荟萃分析，以分析产前PFAS暴露与出生结局之间的关系，包括早产（PTB），低出生体重（LBW），小于胎龄（SGA）和流产。提取比值比（OR）和相应的置信区间进行分析。根据纳入研究的异质性，分别采用固定效应（I2≤ 50%）和随机效应（I2> 50%）模型。全氟辛烷磺酸与肺结核（合并OR = 1.54，95% CI：1.20-1.98）、全氟辛酸与流产（合并OR = 1.40，95% CI：1.15-1.70）以及全氟辛烷磺酸与低出生体重（合并OR = 1.52，95% CI：1.19-1.94）之间存在显著关联。不同研究地区、采样时间和用于PFAS评估的样本类型的纳入研究之间存在差异。这些发现可能为生产含有PFAS的产品的风险评估和决策提供见解。
Although previous meta-analyses have shown that prenatal PFASs exposure is associated with reduction in birth weight, effects of prenatal PFASs exposure on birth outcomes have not been fully explored. We conducted a meta-analysis of 23 eligible studies searched from Embase, PubMed, and Web of Science before March 21, 2021 to analyze the association between prenatal PFASs exposure and birth outcomes, including premature birth (PTB), low birth weight (LBW), small for gestational age (SGA) and miscarriage. Odds ratio (OR) and corresponding confidence intervals were extracted for analysis. According to the heterogeneity of the included studies, fixed-effects (I2≤ 50%) and random-effects (I2> 50%) models were applied respectively. The significant associations between PFOS and PTB (pooled OR = 1.54, 95% CI: 1.20–1.98), PFOA and miscarriage (pooled OR = 1.40, 95% CI: 1.15–1.70), and PFOS and LBW (pooled OR = 1.52, 95% CI: 1.19–1.94) were obtained. There were differences between included studies with different study regions, sampling time, and samples type used for PFASs assessment. These findings may provide insight in risk assessment and decision-making in producing products that contain PFASs.