STUDIES ON HUMAN BILE .4. INFLUENCE OF INGESTION OF CHOLESTEROL IN FORM OF EGGS ON COMPOSITION OF BILE IN HEALTHY SUBJECTS
STUDIES ON HUMAN BILE .4. INFLUENCE OF INGESTION OF CHOLESTEROL IN FORM OF EGGS ON COMPOSITION OF BILE IN HEALTHY SUBJECTS
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DOI：
10.1007/bf02020929
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
FENGER, HJ
中科院分区：
文献类型：
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作者：
DAM, H;PRANGE, I;FENGER, HJ
9名健康青年志愿者接受了连续两个阶段的3周饮食，每天提供5 - 10个鸡蛋（1.03-2.06g鸡蛋胆固醇）。每100卡路里的蛋白质和脂肪的量在所有饮食中是相同的。在鸡蛋方案开始之前以及开始之后3周和6周，在注射胆囊收缩素之后收集十二指肠胆汁样品，并分析pH、干物质、胆固醇、脂溶性磷、甘氨胆酸、甘氨鹅脱氧胆酸、甘氨脱氧胆酸、牛磺胆酸和牛磺鹅去氧胆酸加牛磺去氧胆酸。在收集胆汁的同时，采集血液样品用于测定血清总胆固醇。主要结果如下：血清总胆固醇在鸡蛋喂养期间升高，胆汁中不同胆汁酸在总胆汁酸中的分布无明显变化。总胆汁酸与胆固醇的比值以及脂溶性磷与胆固醇的比值的主要变化是轻微至中度的增加，因此，尽管血清胆固醇增加，但结果并未提供胆固醇在胆汁中溶解度降低的证据。
Nine healthy young volunteers received diets furnishing from 5 to 10 eggs (1.03–2.06g egg cholesterol) per day through two consecutive periods of 3 weeks. The amounts of proteins and fat per 100 calories were the same in all the diets.Immediately before, and 3 and 6 weeks after beginning of the egg regimen, samples of duodenal bile were collected, after injection of cholecystokinin, and analyzed with respect to pH, dry matter, cholesterol, lipid-soluble phosphorus, glycocholic acid, glycochenodeoxycholic acid, glycodeoxycholid acid, taurocholic acid and taurochenodeoxycholic plus taurodeoxycholic acids. Simultaneously with the collection of bile, blood samples were taken for determination of serum total cholesterol. The main results were as follows:Serum total cholesterol increased during the egg regimen.In the bile no great changes occurred in the distribution of the different bile acids in the total bile acids. The predominant change of the ratios between total bile acids and cholesterol and between lipid-soluble phosphorus and cholesterol was a slight to moderate increase.Thus, the results did not provide evidence for a lessening of the solubility of cholesterol in the bile in spite of the fact that serum cholesterol increased.