Associations of pregnancy complications and neonatal characteristics with bipolar disorder in the offspring: Nationwide cohort and sibling-controlled studies.
Associations of pregnancy complications and neonatal characteristics with bipolar disorder in the offspring: Nationwide cohort and sibling-controlled studies.
复制标题
妊娠并发症和新生儿特征与后代双相情感障碍的关联：全国队列和兄弟姐妹对照研究。
DOI：
10.1111/bdi.13327
复制
发表时间：
2023
影响因子：
5.4
通讯作者：
Villamor,Eduardo
中科院分区：
文献类型：
--
作者：
Beer,RachaelJ;Cnattingius,Sven;Susser,EzraS;Villamor,Eduardo
ObjectivesTo investigate associations of neonatal characteristics and pregnancy complications with bipolar disorder（BPD）in offspring.MethodsWe carried an national cohort study among 2，059，578 non-malformed singleton living-birds in Sweden born 1983-2004.使用国家登记处前瞻性记录的信息，我们随访了13至34岁的BPD诊断参与者。我们使用调整后的考克斯模型的风险比（HR）和95%置信区间（CI）比较了暴露类别之间的BPD风险。我们还对1，467，819名同胞进行了同胞对照分析。25岁时BPD的风险为0.74%。极早产（22 - 31周）与同胞对照分析中BPD HR增加相关;与胎龄37周相比，31、28和22周的校正HR（95% CI）分别为1.31（0.99，1.74）、2.09（1.15，3.79）和5.74（1.15，28.63）。自发性但无医学指征的极/极早产与风险增加相关。与阴道分娩相比，剖腹产在一般人群和同胞人群中的BPD风险分别高出1.20（1.08，1.33）和1.58（1.06，2.36）倍。在一般队列和同胞分析中，小于胎龄儿（SGA）出生与BPD HR增加相关（HR [95% CI]分别为1.22 [1.06，1.39]和1.68 [1.13，2.50]）;仅足月SGA与风险增加相关。胎龄头围、妊娠期糖尿病、先兆子痫和胎盘早剥与BPD.ConclusionsVery/extremely preterm breath、剖腹产和SGA均与BPD发病率相关。
ObjectivesTo investigate associations of neonatal characteristics and pregnancy complications with bipolar disorder (BPD) in offspring.MethodsWe conducted a nationwide cohort study among 2,059,578 non‐malformed singleton live‐births in Sweden born 1983–2004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from 13 up to 34 years of age. We compared BPD risks between exposure categories using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling‐controlled analyses among 1,467,819 full siblings.ResultsThere were 14,998 BPD diagnoses. Risk of BPD was 0.74% through 25 years of age. Very/extremely preterm birth (22 to 31 weeks) was related to increased BPD HRs in sibling‐controlled analyses; compared with a gestational age of 37 weeks, adjusted HR (95% CI) for 31, 28, and 22 weeks were, respectively, 1.31 (0.99, 1.74), 2.09 (1.15, 3.79), and 5.74 (1.15, 28.63). Spontaneous but not medically indicated very/extremely preterm birth was associated with increased risk. Compared with vaginal birth, caesarean section birth was associated with 1.20 (1.08, 1.33) and 1.58 (1.06, 2.36) times higher BPD risk in general and sibling cohorts, respectively. Small‐for‐gestational age (SGA) birth was related to increased BPD HRs in general cohort and sibling analyses (HRs [95% CI] were 1.22 [1.06, 1.39] and 1.68 [1.13, 2.50], respectively); only term SGA was associated with increased risk. Head circumference‐for‐gestational age, gestational diabetes, preeclampsia, and placental abruption were not associated with BPD.ConclusionsVery/extremely preterm birth, caesarean birth, and SGA are related to BPD incidence.