Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes
Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes
复制标题
DOI：
10.1152/ajpendo.00549.2003
复制
发表时间：
2004-07-01
影响因子：
5.1
通讯作者：
Rizza, RA
中科院分区：
文献类型：
--
作者：
Basu, R;Schwenk, WF;Rizza, RA
为了确定 2 型糖尿病患者空腹内源性葡萄糖生成 (EGP) 和葡萄糖消失 (R-d) 的调节是否均异常，我们对 7 名“重度”(SD)、9 名“轻度”(MD) 和 12 名非糖尿病 (ND) 受试者（12.7+/-0.6 vs. 8.1+/-0.4 vs. 5.1+/-0.4 mmol/l）在禁食过夜后测量了 EGP 和 R-d。在高血糖胰腺钳夹期间。 SD 和 MD 受试者的空腹胰岛素均高于 ND 受试者，而仅空腹胰高血糖素增加（P
To determine whether regulation of fasting endogenous glucose production (EGP) and glucose disappearance (R-d) are both abnormal in people with type 2 diabetes, EGP and R-d were measured in 7 "severe" (SD), 9 "mild" (MD), and 12 nondiabetic (ND) subjects (12.7+/-0.6 vs. 8.1+/-0.4 vs. 5.1+/-0.4 mmol/l) after an overnight fast and during a hyperglycemic pancreatic clamp. Fasting insulin was higher in both the SD and MD than ND subjects, whereas fasting glucagon only was increased (P