FATTY-ACID OXIDATION AND GLUCOSE-UTILIZATION INTERACT TO CONTROL FOOD-INTAKE IN RATS
FATTY-ACID OXIDATION AND GLUCOSE-UTILIZATION INTERACT TO CONTROL FOOD-INTAKE IN RATS
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DOI：
10.1152/ajpregu.1986.251.5.r840
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发表时间：
1986-11-01
影响因子：
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通讯作者：
TORDOFF, MG
中科院分区：
文献类型：
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作者：
FRIEDMAN, MI;TORDOFF, MG
为了确定葡萄糖和脂肪代谢是否相互作用以控制食物摄入，向大鼠施用2-脱氧葡萄糖（2-DG）（其抑制葡萄糖利用）和棕榈酸甲酯（MP）（其抑制脂肪酸氧化）。2-DG和MP联合处理以协同方式增加摄食量。甚至在单独使用两种药剂不增加食物摄入的剂量下也观察到这种协同效应，并且根据测试条件，其通过开始进食或延长进食来表示。循环底物、肝糖原和胃内容物的代谢测量证实了药物具有其预期的代谢作用，并且没有证据表明一种药物增强了另一种药物的直接代谢作用。结果提供了直接的证据，葡萄糖和脂肪代谢发挥协调控制的摄食行为，并建议存在一个共同的综合机制，控制。
To determine whether glucose and fat metabolism interact to control food intake, rats were administered 2-deoxyglucose (2-DG), which inhibits glucose utilization, and methyl palmoxirate (MP), which inhibits fatty acid oxidation. Combined treatment wiht 2-DG and MP increased food intake in a synergistic fashion. This synergistic effect was observed even at doses of the two agents that alone did not increase food intake, and it was expressed by either an initiation of eating or a prolonged bout of eating, depending on the testing conditions. Metabolic measures of circulating substrates, liver glycogen, and gastric contents confirmed that the drugs had their intended metabolic effects and revealed no evidence that one drug enhanced the direct metabolic action of the other. The results provide direct evidence that glucose and fat metabolism exert a coordinated control over feeding behavior and suggest the existence of a common integrative mechanism in that control.