Musculoskeletal Complications of Severe Acute Respiratory Syndrome
Musculoskeletal Complications of Severe Acute Respiratory Syndrome
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DOI：
10.1055/s-0031-1293500
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发表时间：
2011-11-01
影响因子：
1.4
通讯作者：
Griffith, James F.
中科院分区：
文献类型：
--
作者：
Griffith, James F.
严重急性呼吸系统综合征（SARS）是2003年初在中国南方出现的一种高度传染性肺炎。大量SARS患者出现大关节痛，尽管这在大多数情况下与磁共振成像的任何异常无关。SARS的主要肌肉骨骼并发症是骨坏死和骨量减少，这些并发症不是由疾病本身引起的，而是用大剂量类固醇治疗SARS的结果。SARS患者几乎普遍未接受过类固醇治疗，没有其他已知的骨坏死倾向。SARS患者接受类固醇治疗后骨坏死的发生率为5%~ 58%。骨坏死最常累及股骨近端和股骨髁，与类固醇累积剂量和类固醇治疗持续时间最密切相关。骨坏死风险为
The severe acute respiratory syndrome (SARS) was a highly infectious pneumonia that emerged in southern China early in 2003. A large number of SARS patients experienced large joint arthralgia, although this was, for the most part, not associated with any abnormality on magnetic resonance imaging. The main musculoskeletal complications of SARS were osteonecrosis and reduced bone mass, and these arose not from the disease per se but as a sequel to treatment of SARS with high-dose steroids. SARS patients were almost universally steroid naive with no other known predisposition to osteonecrosis. Prevalence of osteonecrosis in SARS patients treated with steroids ranged from 5% to 58%. Ostconecrosis most commonly affected the proximal femur and femoral condyles and was most strongly related to cumulative steroid dose and duration of steroid therapy. Osteonecrosis risk was