Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents.
Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents.
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DOI：
10.1039/c5cc01833a
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发表时间：
2015-04
影响因子：
4.9
通讯作者：
Hai Wang;Shuting Zhao;P. Agarwal;J. Dumbleton;Jianhua Yu;Xiongbin Lu;Xiaoming He
中科院分区：
文献类型：
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作者：
Hai Wang;Shuting Zhao;P. Agarwal;J. Dumbleton;Jianhua Yu;Xiongbin Lu;Xiaoming He
在本研究中，通过多次（最多4次）乳化制备了多层ph响应聚合物纳米颗粒（NPs），以封装多种亲水和疏水治疗药物，以控制和顺序释放。研究发现，多种化疗药物从NPs释放的顺序显著影响其对癌细胞的疗效。
In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.