ACCELERATED PUBLICATION The mitochondrial citrate carrier: a new player in inflammation
ACCELERATED PUBLICATION The mitochondrial citrate carrier: a new player in inflammation
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DOI：
10.1042/bj20111275
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发表时间：
2011-09-15
影响因子：
4.1
通讯作者：
Iacobazzi, Vito
中科院分区：
文献类型：
--
作者：
Infantino, Vittoria;Convertini, Paolo;Iacobazzi, Vito
线粒体 CIC（柠檬酸盐载体）催化柠檬酸盐从线粒体基质流出，以交换胞质苹果酸。在本文中，我们发现脂多糖激活的免疫细胞中 CIC mRNA 和蛋白质显着增加。此外，CIC基因沉默和CIC活性抑制显着减少NO、活性氧和前列腺素的产生。这些结果首次证明 CIC 在炎症中发挥着关键作用。
The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.