The functional cycle of visual arrestins in photoreceptor cells.
The functional cycle of visual arrestins in photoreceptor cells.
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DOI：
10.1016/j.preteyeres.2011.07.002
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发表时间：
2011-11
影响因子：
17.8
通讯作者：
Gurevich EV
中科院分区：
文献类型：
--
作者：
Gurevich VV;Hanson SM;Song X;Vishnivetskiy SA;Gurevich EV
视觉抑制蛋白-1在视紫红质信号的快速和可重复的关闭中起着关键作用。它与光激活的磷酸化视紫红质的高度选择性结合是视杆细胞光感受器功能完善的组成部分。结构-功能研究揭示了确保arrestin-1选择性的复杂分子机制的关键要素，并为arrestin-1分子的靶向操作铺平了道路，以设计可以补偿视紫红质磷酸化中先天性缺陷的突变体。Arrestin-1自缔合和光依赖性易位在感光细胞中一起工作，以保持外节中活性视紫红质结合arrestin-1单体的恒定供应。最近发现arrestin-1与其他信号蛋白的相互作用表明，它是一个比以前认为的更通用的信号调节器，影响突触末梢和杆存活的功能。阐明arrestin-1与视紫红质和其他结合伴侣相互作用的精细分子机制对于全面理解视杆细胞功能以及设计新的分子工具和治疗视觉障碍的治疗方法是必要的。
Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling. Its highly selective binding to light-activated phosphorylated rhodopsin is an integral part of the functional perfection of rod photoreceptors. Structure-function studies revealed key elements of the sophisticated molecular mechanism ensuring arrestin-1 selectivity and paved the way to the targeted manipulation of the arrestin-1 molecule to design mutants that can compensate for congenital defects in rhodopsin phosphorylation. Arrestin-1 self-association and light-dependent translocation in photoreceptor cells work together to keep a constant supply of active rhodopsin-binding arrestin-1 monomer in the outer segment. Recent discoveries of arrestin-1 interaction with other signaling proteins suggest that it is a much more versatile signaling regulator than previously thought, affecting the function of the synaptic terminals and rod survival. Elucidation of the fine molecular mechanisms of arrestin-1 interactions with rhodopsin and other binding partners is necessary for the comprehensive understanding of rod function and for devising novel molecular tools and therapeutic approaches to the treatment of visual disorders.
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影响因子：
4.8
作者：
Bayburt, Timothy H.;Vishnivetskiy, Sergey A.;Gurevich, Vsevolod V.
通讯作者：
Gurevich, Vsevolod V.
DOI：
10.1073/pnas.84.24.8879
发表时间：
1987-12-01
影响因子：
11.1
作者：
BENOVIC, JL;KUHN, H;LEFKOWITZ, RJ
通讯作者：
LEFKOWITZ, RJ
影响因子：
5.3
作者：
Burns, ME;Mendez, A;Chen, J
通讯作者：
Chen, J
影响因子：
4.3
作者：
Caruso G;Bisegna P;Lenoci L;Andreucci D;Gurevich VV;Hamm HE;DiBenedetto E
通讯作者：
DiBenedetto E
影响因子：
4.8
作者：
Bentmann, A;Schmidt, M;Burmester, T
通讯作者：
Burmester, T