Prediction of prognosis in oral squamous cell carcinoma using infrared microspectroscopy
Prediction of prognosis in oral squamous cell carcinoma using infrared microspectroscopy
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DOI：
10.1002/cam4.7094
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发表时间：
2024-03-01
期刊：
影响因子：
4
通讯作者：
Risk，Janet M.
中科院分区：
文献类型：
--
作者：
Whitley，Conor A.;Ellis，Barnaby G.;Risk，Janet M.
口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）的预后在术前评估是不准确的，只有在随后的原发肿瘤和切除的淋巴结的病理分析后才能被评估。因此，一部分患者治疗过度，发病率增加，或治疗不足，边缘不足，有复发风险。我们假设，这是可能的，以准确的红外光谱诊断活检所产生的临床结果。在这第一步中，我们将存活率与来自原发性tumor.MethodsInfrared光谱相关联，从29例OSCC患者的肿瘤组织中收集红外光谱，并进行分类modeling.ResultsThe模型在预后方面的AUROC中位数为0.89，特异性中位数为0.83，单变量考克斯比例风险模型的风险比为6.29。结论FTIR光谱可作为口腔鳞癌预后的早期生物标志物。
BackgroundEstimation of prognosis of oral squamous cell carcinoma (OSCC) is inaccurate prior to surgery, only being effected following subsequent pathological analysis of the primary tumour and excised lymph nodes. Consequently, a proportion of patients are overtreated, with an increase in morbidity, or undertreated, with inadequate margins and risk of recurrence. We hypothesise that it is possible to accurately characterise clinical outcomes from infrared spectra arising from diagnostic biopsies. In this first step, we correlate survival with IR spectra derived from the primary tumour.MethodsInfrared spectra were collected from tumour tissue from 29 patients with OSCC and subject to classification modelling.ResultsThe model had a median AUROC of 0.89 with regard to prognosis, a median specificity of 0.83, and a hazard ratio of 6.29 in univariate Cox proportional hazard modelling.ConclusionThe data suggest that FTIR spectra may be a useful early biomarker of prognosis in OSCC.