Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk.
Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk.
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DOI：
10.1155/2020/5950813
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发表时间：
2020-01-01
影响因子：
--
通讯作者：
Shaposhnik, Igor I
中科院分区：
文献类型：
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作者：
Genkel, Vadim V;Shaposhnik, Igor I
本文讨论了医学科学各个分支中致病异质性概念化的现代方法。考虑了内表型、内型和残余心血管风险的概念及其在内科和心脏病学中的应用范围。根据动脉粥样硬化遗传结构的最新研究结果，提出了动脉粥样硬化的五种内型。所呈现的每一种内型代表一种或另一种动脉粥样硬化形成的病理生理学机制，具有已确定的遗传底物、生物标志物的特征组和许多临床特征。简要回顾了动脉粥样硬化内型研究的临床意义和前景。
The article discusses modern approaches to the conceptualization of pathogenetic heterogeneity in various branches of medical science. The concepts of endophenotype, endotype, and residual cardiovascular risk and the scope of their application in internal medicine and cardiology are considered. Based on the latest results of studies of the genetic architecture of atherosclerosis, five endotypes of atherosclerosis have been proposed. Each of the presented endotypes represents one or another pathophysiological mechanism of atherogenesis, having an established genetic substrate, a characteristic panel of biomarkers, and a number of clinical features. Clinical implications and perspectives for the study of endotypes of atherosclerosis are briefly reviewed.