Cascade reaction involving Diels–Alder cascade: modular synthesis of amino α-pyrones, indolines and anilines
Cascade reaction involving Diels–Alder cascade: modular synthesis of amino α-pyrones, indolines and anilines
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DOI：
10.1039/c8qo00939b
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发表时间：
2018-12
影响因子：
5.4
通讯作者：
Y. Shen;Chaorong Wang;Wei Chen-;Sunliang Cui
中科院分区：
文献类型：
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作者：
Y. Shen;Chaorong Wang;Wei Chen-;Sunliang Cui
Diels-Alder反应是合成六元碳环和杂环的一种著名而有用的方法，扩展其威力的研究引起了人们极大的兴趣。在这里，我们开发了一种偶联反应作为Diels-Alder反应的前体，用于模块合成氨基α-吡喃，并建立了获得吲哚和苯胺的Diels-Alder级联反应。该方案具有原料易得、底物范围广、合成实用价值高等特点。
The Diels–Alder reaction is a famous and useful method for the synthesis of six-membered carbocycles and heterocycles, and the investigation to extend its power draws tremendous interests. Herein, we develop a coupling reaction for the modular synthesis of amino α-pyrones as Diels–Alder reaction precursors, and also establish the Diels–Alder cascade for obtaining indolines and anilines. This protocol features readily available starting materials, broad substrate scope and valuable synthetic utility.