History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2
History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2
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DOI：
10.1038/sj.onc.1208980
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发表时间：
2005-09-05
期刊：
影响因子：
8
通讯作者：
Gallo, RC
中科院分区：
文献类型：
--
作者：
Gallo, RC
HTLV-1于1979年在美国被发现，并于1980年发表。1981年初，紧接着又有4篇报道描述了另外的分离株、一些HTLV-1蛋白的特性、指示HTLV-1感染的特异性抗体的血清学测定以及感染细胞中整合DNA前病毒的证据。这些早期的工作都不依赖于或受某些T细胞恶性肿瘤的亚分类为ATL（在日本）的影响。相反，美国和欧洲的许多研究人员对导致动物白血病的逆转录病毒的研究工作激励了我，我们的发现是通过我们在20世纪70年代开发的技术方法实现的，这些技术方法包括对逆转录病毒作为替代标记物的特别敏感的检测，以及我们发现的IL-2，这使得培养人类T细胞成为可能。然而，在我们的报告之后，在日本分离出了相同的病毒，两个研究组都提供了HTLV-1引起ATL的证据，ATL是日本首次发现的T细胞恶性肿瘤的一个亚类。
HTLV-1 was discovered in the US in 1979, and published in 1980. This was rapidly followed by four additional reports in early 1981 describing additional isolates, characterization of some of the HTLV-1 proteins, serological assays for specific antibodies indicative of HTLV-1 infection, and evidence for integrated DNA proviruses in infected cells. None of this early work was dependent upon or influenced by the subclassiffication of some T-cell malignancies as ATL (in Japan). Instead, I was stimulated by prior work from many investigators in the US and Europe on retroviruses which caused leukemia in animals and our discoveries were made possible by our technical approaches developed in the 1970s involving especially sensitive assays for RT as a surrogate marker for a retrovirus and our discovery of Il-2 which made it possible to culture human T cells. However, following our reports the same virus was isolated in Japan, and both groups provided evidence that HTLV-1 caused ATL, a subclassification of T-cell malignancies first recognized in Japan.