Age changes in the lumbar intervertebral disc studied with magnetic resonance and cryomicrotomy
Age changes in the lumbar intervertebral disc studied with magnetic resonance and cryomicrotomy
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通过磁共振和冷冻切片研究腰椎间盘的年龄变化
DOI：
10.1002/ca.980010203
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发表时间：
1988
期刊：
影响因子：
2.4
通讯作者：
V. Haughton
中科院分区：
文献类型：
--
作者：
M. Wagner;L. Sether;Shiwei Yu;P. Ho;V. Haughton
这是根据年龄组对腰椎间盘矢状面大体和组织学冷冻切片与磁共振（MR）图像之间的相关性进行的原始评估。年龄相关的结构变化在出生至73岁的尸体椎间盘的解剖切片和MR图像中被识别出来。在T2加权MR图像中，核和纤维软骨内环信号明亮，而周围环纤维信号强度低。随着年龄的增长，椎间盘的纤维性逐渐增强：外周环变宽，纤维性变密，内环向中央延伸，侵入核，有时形成二叶状核。新生儿椎间盘的组成清晰地划分为一个大的、位于中心的髓核和一个相对狭窄的纤维环。在成人中，核和内环在MR图像中继续具有相对明亮的信号，并且特征性地包含一个低信号强度的暗带，这并不对应于椎间盘的裂口或撕裂，而是纤维组织含量的增加。增厚的外周环形纤维信号强度很低。到80岁时，椎间盘具有非常高的纤维含量，MR图像显示信号强度降低，解剖切片上核和环之间没有明显区别。在成年椎间盘的MR图像中，椎间盘中央部分的暗带仍然是一个特征。椎间盘的退行性改变在MR图像上通过对比信号强度来识别。
This is an original evaluation made on the correlation between sagittal gross and histologic cryomicrotome sections and magnetic resonance (MR) images of the lumbar intervertebral discs according to age groups. Age‐related structural changes were recognized in the anatomic sections and MR images of the discs in cadavers from birth to 73 years of age. In T2‐weighted MR images, the nucleus and fibrocartilaginous inner anulus have a bright signal while the peripheral annular fibers have a low signal intensity. With aging the discs become progressively more fibrous: the peripheral anulus widens and becomes densely fibrous and the inner anulus extends centrally to encroach upon the nucleus, sometimes producing a bilobed nucleus. In the newborn the components of the disc are sharply demarcated with a large, centrally located nucleus pulposus and a relatively narrow anulus fibrosus. In the adult, the nucleus and inner anulus continue to have a relatively bright signal in MR images and characteristically contain a dark band of low signal intensity which does not correspond to clefts or tears of the disc but to increased fibrous tissue content. The thickened peripheral annular fibers have a very low signal intensity. By the eighth decade of life the discs have a very high fibrous content throughout, indicated in MR images by a decreased signal intensity with no sharp distinction between nucleus and anulus in the anatomic sections. The dark band in the central portion of the disc remains as a characteristic feature in MR images of the adult disc. Degenerative changes in the discs are identified in MR images by contrasting signal intensities.