Reduced volume of the putamen in REM sleep behavior disorder patients
Reduced volume of the putamen in REM sleep behavior disorder patients
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DOI：
10.1016/j.parkreldis.2010.08.014
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发表时间：
2010-12-01
影响因子：
4.1
通讯作者：
Schiess, Mya C.
中科院分区：
文献类型：
--
作者：
Ellmore, Timothy M.;Hood, Ashley J.;Schiess, Mya C.
目的：本研究的目的是量化与帕金森病 (PD) 相关的特定皮层下灰质核的体积，作为确定帕金森病非侵入性临床生物标志物的初步步骤。我们假设，有患 PD 风险的 REM 睡眠行为障碍 (RBD) 患者将表现出一种神经元变性模式，反映在 T1 加权 MRI 上纹状体体积减少。方法：我们将经多导睡眠图 (PSG) 证实的 RBD 患者的测量值与年龄/性别匹配的对照受试者组和早期 PD (EPD) 患者 (Hoehn & Yahr < 2) 进行比较。临床测量包括统一帕金森病评定量表 (UPDRS)、定时步态和手指敲击任务、帕金森病问卷 (PDQ-39) 以及单晚 PSG 记录的时间同步视频。体积测量源自高分辨率 T1 加权 3 T MRI 图像。结果：匹配的对照组和 EPD 组在年龄、性别、惯用手和总脑体积方面与 RBD 组在统计学上相似。 RBD 组的双侧壳核体积较小（原始体积和按脑组织体积标准化的体积），此外 UPDRS 和 PDQ-39 存在一些临床损伤。结论：壳核体积减小可能是 RBD 的结构标志物，反映了预测 PD 发展的神经退行性变模式。 (C) 2010 Elsevier Ltd. 保留所有权利，
Objective: The purpose of this study was to quantify volumes of specific subcortical gray matter nuclei implicated in Parkinson's disease (PD) as a preliminary step for identifying a non-invasive clinical biomarker for PD. We hypothesized that REM sleep behavior disorder (RBD) patients, at risk for developing PD, will demonstrate a pattern of neuronal degeneration reflected in reduced striatal volumes on T1-weighted MRI.Methods: We compared measures of RBD patients confirmed by polysomnography (PSG) with groups of age/gender-matched Control subjects and early PD (EPD) patients (Hoehn & Yahr < 2). Clinical measurements included the Unified Parkinson's disease Rating Scales (UPDRS), timed gait and finger tapping tasks, the Parkinson's Disease Questionnaire (PDQ-39), and a time-synchronized video recorded single-night PSG. Volumetric measurements were derived from high-resolution T1-weighted 3 T MRI images.Results: The matched Control and EPD groups were statistically similar to the RBD group in age, gender, handedness, and total brain volumes. The RBD group had smaller bilateral putamen volumes (both raw and normalized by brain tissue volume), in addition to some clinical impairment on the UPDRS and PDQ-39.Conclusions: Reduced putamen volumes may be a structural marker for RBD and reflect a pattern of neurodegeneration that predicts the development of PD. (C) 2010 Elsevier Ltd. All rights reserved,