G protein-mediated ion channel activation.
G protein-mediated ion channel activation.
复制标题
G 蛋白介导的离子通道激活。
DOI：
10.1161/01.hyp.17.5.684
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Breitwieser,GE
中科院分区：
文献类型：
--
作者：
Breitwieser,GE
Guanine nucleotide binding proteins couple a wide variety of receptors to ion channels via both "direct" or membrane-delimited and "indirect" second messenger-mediated pathways. This tutorial summarizes current approaches to defining the mechanisms of guanine nucleotide binding protein-mediated ion channel activation. Two well-characterized ion channels in the heart, namely, the beta-adrenergic receptor-activated calcium channel and the muscarinic receptor-activated potassium channel, are used to illustrate the criteria that can distinguish between direct and indirect guanine nucleotide binding protein-transduced pathways.
