Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
Genetic versus environmental aetiology of the metabolic syndrome among male and female twins
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DOI：
10.1007/s001250051659
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发表时间：
2001-05-01
期刊：
影响因子：
8.2
通讯作者：
Beck-Nielsen, H
中科院分区：
文献类型：
--
作者：
Poulsen, P;Vaag, A;Beck-Nielsen, H
目的/假设。代谢综合征的病因包括高胰岛素血症、葡萄糖耐受不良、血脂异常？高血压和肥胖症是未知的。我们研究了遗传因素与环境因素对男性和女性双胞胎中综合征组分发展的相对影响。共有303对老年双胞胎参与了这项研究。我们报告的一致性和遗传力估计的组成部分，通过经典的双胞胎分析，以评估的比例的变化归因于遗传因素。所有组分均显著相关。葡萄糖耐受不良、总体肥胖和低HDL-胆固醇的一致率在单卵双胞胎中显著高于双卵双胞胎，表明这些表型的发展受到遗传影响。葡萄糖浓度的遗传力估计。单卵双胞胎的BMI和HDL-胆固醇证实了这些发现。然而，腰臀比、空腹胰岛素和甘油三酯的遗传力估计值较低，表明环境影响较大。我们发现，较高的遗传影响，葡萄糖耐量和收缩压和低HDL-胆固醇和舒张压男性双胞胎之间的遗传影响较低，女性双胞胎相比。基于综合征中各组分之间的相关性，我们提出了一个核心复合体，包括高胰岛素血症、肥胖、高胆固醇血症和低HDL-胆固醇，与血糖浓度和血压水平仅弱相关。该研究证实了包括遗传和非遗传因素在内的多因素病因学的概念。男性和女性双胞胎之间病因学的差异表明性别对代谢综合征的几个组成部分的影响。
Aims/hypothesis. The aetiology of the metabolic syndrome including hyperinsulinaemia, glucose intolerance, dyslipidaemia? hypertension and obesity is not known. We studied the relative impact of genetic versus environmental factors for the development of the components in the syndrome among male and female twins.Methods. A total of 303 elderly twin pairs participated in the study. We report concordances and heritability estimates of the components by classic twin analysis to assess the proportion of variation attributed to genetic factors.Results. AII components correlated significantly. The concordance rates for glucose intolerance, overall obesity and low HDL-cholesterol were significantly higher among monozygotic than dizygotic twins indicating a genetic influence on the development of these phenotypes. The heritability estimates for glucose concentration. BMI and HDL-cholesterol among monozygotic twins confirmed these findings. The heritability estimates for waist-to-hip ratio, fasting insulin and triglycerides, however were low, indicating a major environmental influence. We found a higher genetic influence on glucose intolerance and systolic blood pressure and a lower genetic influence on low HDL-cholesterol and diastolic blood pressure among male twins compared to female twins.Conclusion/interpretation. Based on the correlations between the components in the syndrome, we propose a core complex including hyperinsulinaemia, obesity hypertriglyceridaemia and low HDL-cholesterol with only weak associations to glucose concentrations and blood pressure levels, The study confirms the notion of a multifactorial aetiology of the components including genetic and non-genetic factors. The differences in aetiology between male and female twins indicate an influence of sex on several of the components in the metabolic syndrome.