FUSIDIC ACID BINDING TO SERUM-ALBUMIN AND INTERACTION WITH BINDING OF BILIRUBIN
FUSIDIC ACID BINDING TO SERUM-ALBUMIN AND INTERACTION WITH BINDING OF BILIRUBIN
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DOI：
10.1111/j.1651-2227.1985.tb10051.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
BRODERSEN, R
中科院分区：
文献类型：
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作者：
BRODERSEN, R
熔融钠是一种用于葡萄球菌感染中的抗生素，与胆红素竞争性地与人血清白蛋白有很强的结合。它的摩尔量足以占据相当大的循环白蛋白。为了避免胆红素脑病的风险，胆红素的位移引起，应谨慎给予新生婴儿，特别是如果患者过早出生，秋葵或酸性。熔融不会干扰华法林或地西ep的白蛋白结合。
Sodium fusidate, an antibiotic used in staphylococcal infections, is strongly bound to human serum albumin, competitively with bilirubin. It is given in molar amounts sufficient to occupy a considerable fraction of circulating albumin. In order to avoid a risk of bilirubin encephalopathy, induced by displacement of bilirubin, fusidate should be given with caution to newborn infants, particularly if patients are prematurely born, icteric or acidotic. Fusidate does not interfere with albumin binding of warfarin or diazepam.