Nanoparticle delivery of natural products in the prevention and treatment of cancers: current status and future prospects.
Nanoparticle delivery of natural products in the prevention and treatment of cancers: current status and future prospects.
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DOI：
10.3390/cancers3044024
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发表时间：
2011-10-26
期刊：
影响因子：
5.2
通讯作者：
Mousa, Shaker A
中科院分区：
文献类型：
--
作者：
Bharali, Dhruba J;Siddiqui, Imtiaz A;Mousa, Shaker A
纳米技术的出现对21世纪生活的许多方面产生了革命性的影响。纳米技术为探索传统技术无法影响的新途径提供了机会，用于诊断，预防和治疗不同疾病，特别是癌症。纳米尺寸的实体是掺入各种药物或活性材料的极好平台，所述药物或活性材料可以有效地递送到所需的作用部位而不损害掺入的药物或材料的活性。特别是，纳米技术实体可用于递送溶解性差或半衰期短的常规天然产品。与纳米尺寸的实体一起使用的常规天然产物使我们能够解决与天然产物相关的许多固有问题（稳定性、溶解性、毒性），并且还提供了靶向递送至肿瘤部位的平台。我们最近介绍了使用纳米技术来提高化学预防效果的新概念，我们称之为“纳米化学预防”。这个想法随后被世界各地的几个实验室利用，现在已经成为化学预防研究的一个前沿领域。本文综述了纳米技术在癌症预防和治疗中的应用。
The advent of nanotechnology has had a revolutionary impact on many aspects of 21st century life. Nanotechnology has provided an opportunity to explore new avenues that conventional technologies have been unable to make an impact on for diagnosis, prevention, and therapy of different diseases, and of cancer in particular. Entities in nanometer sizes are excellent platforms to incorporate various drugs or active materials that can be delivered effectively to the desired action site without compromising the activity of the incorporated drug or material. In particular, nanotechnology entities can be used to deliver conventional natural products that have poor solubility or a short half life. Conventional natural products used with entities in nanometer sizes enable us to solve many of the inherent problems (stability, solubility, toxicity) associated with natural products, and also provide a platform for targeted delivery to tumor sites. We recently introduced the novel concept of using nanotechnology for enhancing the outcome of chemoprevention, which we called 'nanochemoprevention'. This idea was subsequently exploited by several laboratories worldwide and has now become an advancing field in chemoprevention research. This review examines some of the applications of nanotechnology for cancer prevention and therapy using natural products.