LOCALIZATION OF A MEMORY TRACE IN THE MAMMALIAN BRAIN
LOCALIZATION OF A MEMORY TRACE IN THE MAMMALIAN BRAIN
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DOI：
10.1126/science.8493536
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发表时间：
1993-05-14
期刊：
影响因子：
56.9
通讯作者：
THOMPSON, RF
中科院分区：
文献类型：
--
作者：
KRUPA, DJ;THOMPSON, JK;THOMPSON, RF
事实证明，即使对于简单的学习和记忆形式，大脑中记忆形成部位的定位也是一项艰巨的任务。为了定位大脑中记忆形成的特定部位，兔的眨眼反应被经典地调节，而小脑或红核的区域被微量注射伽马氨基丁酸激动剂蝇草酚暂时失活。小脑失活完全阻止了学习，但失活后对随后的学习没有影响，而红核失活并不阻止学习，但确实阻止了条件性反应的表达。因此，这种习得反应的记忆形成部位似乎局限在小脑内。
The localization of sites of memory formation within the brain has proven to be a formidable task even for simple forms of learning and memory. In order to localize a particular site of memory formation within the brain, the rabbit eyeblink response was classically conditioned while regions of the cerebellum or red nucleus were temporarily inactivated by microinfusions of the gamma-aminobutyric acid agonist muscimol. Cerebellar inactivation completely blocked learning but had no effect on subsequent learning after inactivation, whereas red nucleus inactivation did not prevent learning but did block the expression of conditioned responses. The site of memory formation for this learned response thus appears to be localized within the cerebellum.