Changing patterns of tonsillar squamous cell carcinoma in the United States
Changing patterns of tonsillar squamous cell carcinoma in the United States
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DOI：
10.1023/a:1008918223334
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发表时间：
2000-07-01
影响因子：
2.3
通讯作者：
Biggar, RJ
中科院分区：
文献类型：
--
作者：
Frisch, M;Hjalgrim, H;Biggar, RJ
目的：扁桃体鳞状细胞癌(SCC)在病因上可能与其他口腔癌不同。本研究的目的是提供美国扁桃体鳞状细胞癌发病模式的详细描述。方法：使用康涅狄格州肿瘤登记处(1945-1994)和SEER计划(1973-1995)的基于人群的发病率数据来计算年龄标准化(US 1970)和年龄特定发病率和可信区间(CI)。结果：1945-1994年间，康涅狄格州白人女性扁桃体鳞状细胞癌的发病率增加了4倍，而白人男性的发病率基本保持不变。1973-1995年，黑人每百万人年的发病率(男性31.6；95%CI：29.0-34.4，女性9.6；95%CI：8.3-10.9)明显高于白人(14.8；95%CI：14.3-15.3，6.1；95%CI：5.8-6.4)。在1973-1995年间，年龄在60岁以下的男性扁桃体鳞癌发病率每年显著增加(黑人为2.7%，白人为1.9%)。结论：扁桃体鳞状细胞癌的发病率因性别、种族和时间的不同而有很大差异，这种差异不能仅用扁桃体切除方法的改变来解释。环境风险因素的变化，包括吸烟模式的变化和口腔人类乳头瘤病毒感染的增加，可能是原因之一。
Objective: Tonsillar squamous cell carcinoma (SCC) may differ etiologically from other oral cancers. The aim of this study was to provide a detailed description of the incidence patterns of tonsillar SCC in the United States.Methods: Population-based incidence data from the Connecticut Tumor Registry (period 1945-1994) and from the SEER program (period 1973-1995) were used to calculate age-standardized (US 1970) and age-specific incidence rates and confidence intervals (CIs). Linear regression was used to evaluate trends.Results: The incidence of tonsillar SCC increased fourfold among white women in Connecticut during 1945-1994 but remained rather constant in white men. During 1973-1995, incidence rates per million person-years were considerably higher in blacks (31.6; 95% CI: 29.0-34.4 in men, and 9.6; 95% CI: 8.3-10.9 in women) than whites (14.8; 95% CI: 14.3-15.3 in men, and 6.1; 95% CI: 5.8-6.4 in women). Men, but not women, who were younger than 60 years experienced significant annual increases in tonsillar SCC incidence during 1973-1995 (2.7% in blacks and 1.9% in whites). No similar increases occurred for oral SCC at non-tonsillar sites.Conclusion: Incidence rates of tonsillar SCC vary considerably by sex, race and time in a way that cannot be explained by changes in tonsillectomy practices alone. Changes in environmental risk factors, including changes in smoking patterns and an increase in oral human papillomavirus infections, may have contributed.